Pore Helix, Selectivity Filter, and Extracellular Loop Residues Contributing >1 kcal/mole Static Field Energy to the Interaction of K+ along the Pore for Z < 0 Å
| Pore helix, selectivity filter, and extracellular loops . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KirBac1.1 | I89 | V105 | E106 | T107 | L108 | A109 | T110 | V111 | D115 | M116 | P118 | |||||||||||
| Kir1.1 | E111 | L136 | E137 | T138 | Q139 | V140 | T141 | I142 | F146 | R147 | E151 | |||||||||||
| Kir2.1 | A115 | I137 | E138 | T139 | Q140 | T141 | T142 | I143 | F147 | R148 | D152 | |||||||||||
| Kir3.1 | K114 | I138 | E139 | T140 | E141 | A142 | T143 | I144 | Y148 | R149 | D153 | |||||||||||
| Kir6.2 | P102 | I125 | E126 | V127 | Q128 | V129 | T130 | I131 | G135 | R136 | E140 | |||||||||||
| Pore helix, selectivity filter, and extracellular loops . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KirBac1.1 | I89 | V105 | E106 | T107 | L108 | A109 | T110 | V111 | D115 | M116 | P118 | |||||||||||
| Kir1.1 | E111 | L136 | E137 | T138 | Q139 | V140 | T141 | I142 | F146 | R147 | E151 | |||||||||||
| Kir2.1 | A115 | I137 | E138 | T139 | Q140 | T141 | T142 | I143 | F147 | R148 | D152 | |||||||||||
| Kir3.1 | K114 | I138 | E139 | T140 | E141 | A142 | T143 | I144 | Y148 | R149 | D153 | |||||||||||
| Kir6.2 | P102 | I125 | E126 | V127 | Q128 | V129 | T130 | I131 | G135 | R136 | E140 | |||||||||||
Residues are aligned across the five Kir channels to show the variation at each position between strongly contributing residues (bold) and non-electrostatic counterparts (italics). The yellow spheres in Fig. 1 A highlight the positions of these 11 sites.