TABLE II Voltage Dependence of the... | Rockefeller University Press

TABLE II

Voltage Dependence of the Florescence Changes (F × V) in Mutated Nav1.4 Channels Expressed in Xenopus Oocytes

	Control			Ts3 200 nM
	z	V (mV)	z	V (mV)
S4DI (S216C)	0.921 ± 0.004	−76.7 ± 1.2	1.28 ± 0.11^{^a}	−57.6 ± 1.9^{^a}
S4DII (S660C)	0.96 ± 0.02	−59.8 ± 3.4	1.34 ± 0.07^{^a}	−60.2 ± 2.4
S4DIII (L1115C)	1.47 ± 0.07	−70.6 ± 0.7	1.61 ± 0.09	−72.1 ± 4.4
S4DIV (L1439C)	2.26 ± 0.18	−78.2 ± 6.9	1.73 ± 0.09	−59.3 ± 4.3^{^a}

	Control			Ts3 200 nM
	z	V (mV)	z	V (mV)
S4DI (S216C)	0.921 ± 0.004	−76.7 ± 1.2	1.28 ± 0.11^a	−57.6 ± 1.9^a
S4DII (S660C)	0.96 ± 0.02	−59.8 ± 3.4	1.34 ± 0.07^a	−60.2 ± 2.4
S4DIII (L1115C)	1.47 ± 0.07	−70.6 ± 0.7	1.61 ± 0.09	−72.1 ± 4.4
S4DIV (L1439C)	2.26 ± 0.18	−78.2 ± 6.9	1.73 ± 0.09	−59.3 ± 4.3^a

Values are averages of three independent experiments ± SEM.

Values statistically different from control (P < 0.05).