Table 1. Summary of experiments... | Rockefeller University Press

Table 1.

Summary of experiments indicating the role of plasminogen activator system in animal models of disease

Authors	Model	Plasmin(ogen) role	tPA role	uPA role	Fibrin dependent?
Infection
Nordstrand et al., 2001	Plg^−/− mice on C57Bl/6 background	Aids in infection by B. crocidurae
Gebbia et al., 1999	Plg^−/− mice on mixed 129/Black Swiss background	Increases bacterial load in inflammation in brains and hearts of mice treated with B. burgdorferi
Coleman et al., 1995	Human umbilical vein endothelial cells	Aids in B. burgdorferi penetration of endothelium
Guo et al., 2011	Plg^−/−, tPA^−/−, and uPA^−/− mice on C57Bl/6 background	Aids in infection by S. aureus	Aids in infection by S. aureus	Aids in infection by S. aureus
Berri et al., 2013	Plg^−/− mice on C57Bl/6 background	Aids in lung inflammation in response to infection with H5N1 and H1N1 viruses			Yes
Stie and Fox, 2012a, 2012b	Primary cultured BMEC	Used by the fungus C. neoformans to invade its host		Upregulated in response to C. neoformans infection
González-Miguel et al., 2019	Wistar rats	Enhanced generation in response to parasite F. hepatica infection
Silva et al., 2019	Plg^−/− and Fbg^−/− mice on C57Bl/6 background	Necessary for macrophage migration in sterile peritonitis			Yes
Neurological disease
Tsirka et al., 1997a, 1997b	C57Bl/6 mice	Regulates neuronal death in response to acute kainate injection	Regulates microglial activation and neuronal death in response to acute kainate injection		No
Hultman et al., 2014	Plg^−/− mice on a C57Bl/6 background	Promotes neuroinflammation in response to acute LPS challenge			No
Baker et al., 2019	C57Bl/6 mice	Recruits perivascular macrophage migration and microglial activation in response to peripheral LPS challenge
Paul et al., 2007	Plg^−/− AD mice	Contributes to neurovascular damage in a mouse model of AD			Yes
Shaw et al., 2017	Plg^−/− mice on a C57Bl/6 background	Promotes demyelination in EAE model			Yes
Baker et al., 2018	Tg6799 mice	Promotes neuroinflammation and AD pathology
Siao and Tsirka, 2002	tPA^−/− mice on a C57Bl/6 background		Promotes microglial activation in response to LPS
East et al., 2005; Dahl et al., 2016	tPA^−/− mice on a C57Bl/6 background		Protects against early onset and severe demyelination in EAE model		Yes
Lenglet et al., 2014	129/SvEV mice		Increases inflammation following stroke		No
Arthritis
Li et al., 2005	uPA^−/− and Plg^−/− mice on a C57Bl/6 background	Promotes joint inflammation in systemic collagen type II–induced arthritis		Promotes joint inflammation in collagen type II–induced arthritis
Raghu et al., 2014	Plg^−/− mice on a C57Bl/6 background	Prevents joint inflammation in small joints and promotes inflammation in large joints in a monoarticular TNF-α arthritis model			Yes
Cook et al., 2010	uPA^−/− mice on a C57Bl/6 background			Necessary for systemic arthritis development
De Nardo et al., 2010	uPA^−/− mice on a C57Bl/6 background			Limits susceptibility to monoarticular arthritis	Yes
Other
Das et al., 2013	Plg^−/− mice on a C57Bl/6 background	Promotes atherosclerosis progression via regulation of foam cell formation
DeFilippis et al., 2016	Humans with myocardial infarction	Binds to OxPLs to regulate inflammation in myocardial infarction events			Yes
Swaisgood et al., 2007	Plg^−/− mice on a C57Bl/6 background	Promotes mucus production and immune cell recruitment into lungs of ovalbumin-induced asthma model
Li et al., 2011	BALB/c mice	Plasminogen is decreased and plasmin is increased in psoriatic lesions, promoting upregulation of chemokines

Authors	Model	Plasmin(ogen) role	tPA role	uPA role	Fibrin dependent?
Infection
Nordstrand et al., 2001	Plg^−/− mice on C57Bl/6 background	Aids in infection by B. crocidurae
Gebbia et al., 1999	Plg^−/− mice on mixed 129/Black Swiss background	Increases bacterial load in inflammation in brains and hearts of mice treated with B. burgdorferi
Coleman et al., 1995	Human umbilical vein endothelial cells	Aids in B. burgdorferi penetration of endothelium
Guo et al., 2011	Plg^−/−, tPA^−/−, and uPA^−/− mice on C57Bl/6 background	Aids in infection by S. aureus	Aids in infection by S. aureus	Aids in infection by S. aureus
Berri et al., 2013	Plg^−/− mice on C57Bl/6 background	Aids in lung inflammation in response to infection with H5N1 and H1N1 viruses			Yes
Stie and Fox, 2012a, 2012b	Primary cultured BMEC	Used by the fungus C. neoformans to invade its host		Upregulated in response to C. neoformans infection
González-Miguel et al., 2019	Wistar rats	Enhanced generation in response to parasite F. hepatica infection
Silva et al., 2019	Plg^−/− and Fbg^−/− mice on C57Bl/6 background	Necessary for macrophage migration in sterile peritonitis			Yes
Neurological disease
Tsirka et al., 1997a, 1997b	C57Bl/6 mice	Regulates neuronal death in response to acute kainate injection	Regulates microglial activation and neuronal death in response to acute kainate injection		No
Hultman et al., 2014	Plg^−/− mice on a C57Bl/6 background	Promotes neuroinflammation in response to acute LPS challenge			No
Baker et al., 2019	C57Bl/6 mice	Recruits perivascular macrophage migration and microglial activation in response to peripheral LPS challenge
Paul et al., 2007	Plg^−/− AD mice	Contributes to neurovascular damage in a mouse model of AD			Yes
Shaw et al., 2017	Plg^−/− mice on a C57Bl/6 background	Promotes demyelination in EAE model			Yes
Baker et al., 2018	Tg6799 mice	Promotes neuroinflammation and AD pathology
Siao and Tsirka, 2002	tPA^−/− mice on a C57Bl/6 background		Promotes microglial activation in response to LPS
East et al., 2005; Dahl et al., 2016	tPA^−/− mice on a C57Bl/6 background		Protects against early onset and severe demyelination in EAE model		Yes
Lenglet et al., 2014	129/SvEV mice		Increases inflammation following stroke		No
Arthritis
Li et al., 2005	uPA^−/− and Plg^−/− mice on a C57Bl/6 background	Promotes joint inflammation in systemic collagen type II–induced arthritis		Promotes joint inflammation in collagen type II–induced arthritis
Raghu et al., 2014	Plg^−/− mice on a C57Bl/6 background	Prevents joint inflammation in small joints and promotes inflammation in large joints in a monoarticular TNF-α arthritis model			Yes
Cook et al., 2010	uPA^−/− mice on a C57Bl/6 background			Necessary for systemic arthritis development
De Nardo et al., 2010	uPA^−/− mice on a C57Bl/6 background			Limits susceptibility to monoarticular arthritis	Yes
Other
Das et al., 2013	Plg^−/− mice on a C57Bl/6 background	Promotes atherosclerosis progression via regulation of foam cell formation
DeFilippis et al., 2016	Humans with myocardial infarction	Binds to OxPLs to regulate inflammation in myocardial infarction events			Yes
Swaisgood et al., 2007	Plg^−/− mice on a C57Bl/6 background	Promotes mucus production and immune cell recruitment into lungs of ovalbumin-induced asthma model
Li et al., 2011	BALB/c mice	Plasminogen is decreased and plasmin is increased in psoriatic lesions, promoting upregulation of chemokines

Note that fibrinogen dependence is indicated only if it was specifically studied in the particular experiment described. BMEC, brain microvascular endothelial cells.

[ViewLarge]

Sharing Unavailable