Table I. Pathologic evaluation of skin... | Rockefeller University Press

Table I.

Pathologic evaluation of skin lesions after tape stripping

Treatment groups	Epidermis thickness	Ulceration	Intraepithelial inflammation	Dermal inflammation	Panniculum inflammation	Total disease score
(NZBxNZW)F₁ mice	2.9 ± 1.7	1.6 ± 0.2	1.0 ± 0.16	2.3 ± 0.14	1.7 ± 0.12	8.4 ± 0.6
C57BL/6 mice	0.4 ± 0.3^a	0.4 ± 0.4^b	0.4 ± 0.4^b	0.8 ± 0.2^a	1.4 ± 0.3^b	3.4 ± 0.8^a
129 mice	1.0 ± 0.2^a	0.0 ± 0.0^a	0.0 ± 0.0^a	1.6 ± 0.2^a	1.2 ± 0.2^a	3.1 ± 0.4^a
(NZBxNZW)F₁ + IRS 954 (pre-injury)	0.7 ± 0.2^a	0.0 ± 0.0^a	0.2 ± 0.2^b	1.3±0.2^a	0.8 ± 0.1^a	3.2 ± 0.5^a
(NZBxNZW)F₁ + IRS 954 (therapeutic)	1.0 ± 0.2^a	0.2 ± 0.1^a	0.2 ± 0.2^a	1.2 ± 0.1^a	1.0 ± 0.0^a	3.5 ± 0.4^a
(NZBxNZW)F₁ depleted of PDCs	1.4 ± 0.3^b	0.1 ± 0.1^a	0.1 ± 0.1^b	1.4 ± 0.2^a	1.0 ± 0.2^a	4.0 ± 0.5^a

Treatment groups	Epidermis thickness	Ulceration	Intraepithelial inflammation	Dermal inflammation	Panniculum inflammation	Total disease score
(NZBxNZW)F₁ mice	2.9 ± 1.7	1.6 ± 0.2	1.0 ± 0.16	2.3 ± 0.14	1.7 ± 0.12	8.4 ± 0.6
C57BL/6 mice	0.4 ± 0.3^a	0.4 ± 0.4^b	0.4 ± 0.4^b	0.8 ± 0.2^a	1.4 ± 0.3^b	3.4 ± 0.8^a
129 mice	1.0 ± 0.2^a	0.0 ± 0.0^a	0.0 ± 0.0^a	1.6 ± 0.2^a	1.2 ± 0.2^a	3.1 ± 0.4^a
(NZBxNZW)F₁ + IRS 954 (pre-injury)	0.7 ± 0.2^a	0.0 ± 0.0^a	0.2 ± 0.2^b	1.3±0.2^a	0.8 ± 0.1^a	3.2 ± 0.5^a
(NZBxNZW)F₁ + IRS 954 (therapeutic)	1.0 ± 0.2^a	0.2 ± 0.1^a	0.2 ± 0.2^a	1.2 ± 0.1^a	1.0 ± 0.0^a	3.5 ± 0.4^a
(NZBxNZW)F₁ depleted of PDCs	1.4 ± 0.3^b	0.1 ± 0.1^a	0.1 ± 0.1^b	1.4 ± 0.2^a	1.0 ± 0.2^a	4.0 ± 0.5^a

15–23 d after tape stripping, each of the histological features was scored singularly and graded 1 to 3 as indicated in Materials and methods; the overall disease score was calculated by combining the scores for each parameter. Data are from three to four different independent experiments (n = 12–30; mean ± SEM).

P < 0.001 as compared with the (NZBxNZW)F₁ group.

P < 0.05 as compared with the (NZBxNZW)F₁ group.

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