Table 1.

Experimental settings on immune cell function/fate that are associated with CD36 dual functions

Cell typeCell environmentSpeciesCell function/FateReference
Monocytes In vitro culture Human Differentiation to macrophages Huh et al. (1996)  
Monocytes In vitro culture Human Differentiation to DCs Szatmari et al. (2004)  
Macrophages In vitro culture Human and mouse Phagocytosis Greenberg et al. (2006)  
Microglia and macrophages In vitro culture Mouse Cytokine, chemokine secretion and ROS production El Khoury et al. (2003)  
Macrophages In vitro culture Human and mouse Cell motility reduction Park et al. (2009)  
Macrophages In vitro culture Mouse M2-like polarization Vats et al. (2006)  
Macrophages In vitro culture Mouse Inflammasome activation and IL-1β secretion Sheedy et al. (2013)  
DCs In vitro culture Human Efferocytosis Urban et al. (2001)  
Cancer stem cells Tumor Human and mouse Self-renew Hale et al. (2014)  
Leukemic stem cells Gonadal adipose tissue Human and mouse Evade chemotherapy Ye et al. (2016)  
Nonclassical monocytes Peripheral blood vessels Mouse Patrolling along blood vessels Marcovecchio et al. (2017)  
Macrophages Aorta Mouse Foam cell formation Febbraio et al. (2000); Rahaman et al. (2006)  
Macrophages Aorta Human and mouse Mitochondrial ROS production, glycolytic switch Chen et al. (2019)  
Macrophages Tumor Human and mouse Fatty acid oxidation Su et al. (2020)  
Macrophages Adipose tissue Mouse Inflammatory paracrine loop Kennedy et al. (2011)  
MDSCs Tumor Human and mouse Immunosuppression Xin et al. (2021)  
Treg cells Tumor Human and mouse TME adaptation and immunosuppression Wang et al. (2020)  
CD8 T cells Tumor Human and mouse Ferroptosis Ma et al. (2021); Xu et al. (2021)  
B cells Blood Human and mouse Autophagy and humoral immune responses He et al. (2021)  
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