Experimental settings on immune cell function/fate that are associated with CD36 dual functions
| Cell type . | Cell environment . | Species . | Cell function/Fate . | Reference . |
|---|---|---|---|---|
| Monocytes | In vitro culture | Human | Differentiation to macrophages | Huh et al. (1996) |
| Monocytes | In vitro culture | Human | Differentiation to DCs | Szatmari et al. (2004) |
| Macrophages | In vitro culture | Human and mouse | Phagocytosis | Greenberg et al. (2006) |
| Microglia and macrophages | In vitro culture | Mouse | Cytokine, chemokine secretion and ROS production | El Khoury et al. (2003) |
| Macrophages | In vitro culture | Human and mouse | Cell motility reduction | Park et al. (2009) |
| Macrophages | In vitro culture | Mouse | M2-like polarization | Vats et al. (2006) |
| Macrophages | In vitro culture | Mouse | Inflammasome activation and IL-1β secretion | Sheedy et al. (2013) |
| DCs | In vitro culture | Human | Efferocytosis | Urban et al. (2001) |
| Cancer stem cells | Tumor | Human and mouse | Self-renew | Hale et al. (2014) |
| Leukemic stem cells | Gonadal adipose tissue | Human and mouse | Evade chemotherapy | Ye et al. (2016) |
| Nonclassical monocytes | Peripheral blood vessels | Mouse | Patrolling along blood vessels | Marcovecchio et al. (2017) |
| Macrophages | Aorta | Mouse | Foam cell formation | Febbraio et al. (2000); Rahaman et al. (2006) |
| Macrophages | Aorta | Human and mouse | Mitochondrial ROS production, glycolytic switch | Chen et al. (2019) |
| Macrophages | Tumor | Human and mouse | Fatty acid oxidation | Su et al. (2020) |
| Macrophages | Adipose tissue | Mouse | Inflammatory paracrine loop | Kennedy et al. (2011) |
| MDSCs | Tumor | Human and mouse | Immunosuppression | Xin et al. (2021) |
| Treg cells | Tumor | Human and mouse | TME adaptation and immunosuppression | Wang et al. (2020) |
| CD8 T cells | Tumor | Human and mouse | Ferroptosis | Ma et al. (2021); Xu et al. (2021) |
| B cells | Blood | Human and mouse | Autophagy and humoral immune responses | He et al. (2021) |
| Cell type . | Cell environment . | Species . | Cell function/Fate . | Reference . |
|---|---|---|---|---|
| Monocytes | In vitro culture | Human | Differentiation to macrophages | Huh et al. (1996) |
| Monocytes | In vitro culture | Human | Differentiation to DCs | Szatmari et al. (2004) |
| Macrophages | In vitro culture | Human and mouse | Phagocytosis | Greenberg et al. (2006) |
| Microglia and macrophages | In vitro culture | Mouse | Cytokine, chemokine secretion and ROS production | El Khoury et al. (2003) |
| Macrophages | In vitro culture | Human and mouse | Cell motility reduction | Park et al. (2009) |
| Macrophages | In vitro culture | Mouse | M2-like polarization | Vats et al. (2006) |
| Macrophages | In vitro culture | Mouse | Inflammasome activation and IL-1β secretion | Sheedy et al. (2013) |
| DCs | In vitro culture | Human | Efferocytosis | Urban et al. (2001) |
| Cancer stem cells | Tumor | Human and mouse | Self-renew | Hale et al. (2014) |
| Leukemic stem cells | Gonadal adipose tissue | Human and mouse | Evade chemotherapy | Ye et al. (2016) |
| Nonclassical monocytes | Peripheral blood vessels | Mouse | Patrolling along blood vessels | Marcovecchio et al. (2017) |
| Macrophages | Aorta | Mouse | Foam cell formation | Febbraio et al. (2000); Rahaman et al. (2006) |
| Macrophages | Aorta | Human and mouse | Mitochondrial ROS production, glycolytic switch | Chen et al. (2019) |
| Macrophages | Tumor | Human and mouse | Fatty acid oxidation | Su et al. (2020) |
| Macrophages | Adipose tissue | Mouse | Inflammatory paracrine loop | Kennedy et al. (2011) |
| MDSCs | Tumor | Human and mouse | Immunosuppression | Xin et al. (2021) |
| Treg cells | Tumor | Human and mouse | TME adaptation and immunosuppression | Wang et al. (2020) |
| CD8 T cells | Tumor | Human and mouse | Ferroptosis | Ma et al. (2021); Xu et al. (2021) |
| B cells | Blood | Human and mouse | Autophagy and humoral immune responses | He et al. (2021) |