Table 3.

CyTOF profiling of P1 and his family members

Percentage of totalFatherMotherBrotherPatient
pDCs (calculated)0.461.050.370.77
mDCs CD1c+ 0.46 0.75 0.52 0.33 
CD141+ 0.03 0.02 0.01 0.06 
Total 2.63 1.30 0.96 0.98 
Monocytes Mo1 9.71 14.42 12.15 6.82 
Mo2 0.26 0.26 0.37 0.21 
Mo3 0.25 0.29 0.38 0.30 
NK cells NK1 2.81 1.83 3.26 1.00 
NK2 0.24 0.08 0.24 0.32 
NK3 24.32 28.33 20.60 13.87 
T cells      
CD8+ Naive 3.97 12.04 12.27 20.82 
EMRA 2.73 2.36 9.06 9.38 
CM 1.41 2.78 1.30 2.12 
EM 10.08 4.66 6.65 7.38 
CD4+ Naive 16.73 16.88 15.86 20.93 
EMRA 2.61 1.80 2.26 2.05 
CM 9.40 6.11 2.49 4.27 
EM 4.85 2.31 2.15 2.06 
NKT cells 0.00 0.14 0.11 0.05 
CD4+ Th1 2.57 1.03 0.93 1.20 
Th2 29.70 24.50 20.83 27.28 
Th17 0.86 1.22 0.83 0.51 
MAIT 0.245 0.852 0.316 0.036 
ILCs ILC1 0.032 0.077 0.076 0.045 
ILC2 0.017 0.080 0.085 0.03 
ILC3 0.016 0.034 0.058 0.018 
Total 0.026 0.111 0.132 0.027 
Percentage of totalFatherMotherBrotherPatient
pDCs (calculated)0.461.050.370.77
mDCs CD1c+ 0.46 0.75 0.52 0.33 
CD141+ 0.03 0.02 0.01 0.06 
Total 2.63 1.30 0.96 0.98 
Monocytes Mo1 9.71 14.42 12.15 6.82 
Mo2 0.26 0.26 0.37 0.21 
Mo3 0.25 0.29 0.38 0.30 
NK cells NK1 2.81 1.83 3.26 1.00 
NK2 0.24 0.08 0.24 0.32 
NK3 24.32 28.33 20.60 13.87 
T cells      
CD8+ Naive 3.97 12.04 12.27 20.82 
EMRA 2.73 2.36 9.06 9.38 
CM 1.41 2.78 1.30 2.12 
EM 10.08 4.66 6.65 7.38 
CD4+ Naive 16.73 16.88 15.86 20.93 
EMRA 2.61 1.80 2.26 2.05 
CM 9.40 6.11 2.49 4.27 
EM 4.85 2.31 2.15 2.06 
NKT cells 0.00 0.14 0.11 0.05 
CD4+ Th1 2.57 1.03 0.93 1.20 
Th2 29.70 24.50 20.83 27.28 
Th17 0.86 1.22 0.83 0.51 
MAIT 0.245 0.852 0.316 0.036 
ILCs ILC1 0.032 0.077 0.076 0.045 
ILC2 0.017 0.080 0.085 0.03 
ILC3 0.016 0.034 0.058 0.018 
Total 0.026 0.111 0.132 0.027 

CM, central memory; EM, effector memory; EMRA, effector memory cells re-expressing CD45RA; mDC, myeloid dendritic cell; pDC, plasmacytoid dendritic cell.

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