Table 1.
The most recent clinical trials targeting GM-CSF or its receptor in inflammatory/autoimmune disease
TargetMoleculeCompanyIndicationPhaseStatusClinicalTrials.gov identifierReference
GM-CSFR Mavrilimumab/KPL-301 (previously CAM-3001) MedImmune RA IIb Completed NCT01706926 Burmester et al., 2017  
   RA IIb Completed NCT01715896 Guo et al., 2018; Weinblatt et al., 2018  
   RA II (OLE) Terminated NCT01712399 Burmester et al., 2018  
  Kiniksa GCA II Recruiting NCTC5827018  
GM-CSF GSK 3196165/Otilimab (previously MOR103) GSK RA IIb Completed NCT02504671  
   RA IIa Completed NCT02799472 Genovese, M.C., et al. 2018. ACR/ARHP Annual Meeting. Abst. 2510. 
   RA III Recruiting NCT03970837  
   RA III Recruiting NCT03980483  
   Hand OA IIa Completed NCT02683785 Schett, G., et al. 2018. ACR/ARHP Annual Meeting. Abst. 1365. 
 Namilumab (previously MT203) Takeda RA Ib Completed NCT01317797 Huizinga et al., 2017  
   RA II Terminated NCT02393378  
   RA II Completed NCT02379091 Taylor et al., 2019  
   Plaque psoriasis II Completed NCT02129777 Papp et al., 2019  
  Izana Bioscience Axial SpA IIa Recruiting NCT03622658  
 Lenzilumab (previously KB003) Humanigen Asthma II Completed NCT01603277 Molfino et al., 2016  
 TJM2 I-Mab Biopharma  I Recruiting NCT03794180  

GCA, giant cell arteritis; SpA, spondyloarthritis.

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