Table 1.
Specific members of the IL-1 family and their receptors and function
IL-1 family memberReceptor complexFunction
IL-1α IL-1R1/IL-1R3 Proinflammatory 
IL-1β IL-1R1/IL-1R3 Proinflammatory 
IL-18 IL-1R5/IL-1R7 Proinflammatory 
Anti-inflammatory 
IL-37 IL-1R5/IL-1R8 Anti-inflammatory 
IL-1 family memberReceptor complexFunction
IL-1α IL-1R1/IL-1R3 Proinflammatory 
IL-1β IL-1R1/IL-1R3 Proinflammatory 
IL-18 IL-1R5/IL-1R7 Proinflammatory 
Anti-inflammatory 
IL-37 IL-1R5/IL-1R8 Anti-inflammatory 
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