| Protein namea . | CD name . | FCb . | Adjusted P valuec . |
|---|---|---|---|
| Baseline PD vs. SD/PR | |||
| CTLA-4 | CD152 | 1.8 | 0.388 |
| NCAM | CD56 | 1.66 | 0.388 |
| CD45RO | CD45RO | 1.52 | 0.388 |
| d43 PD vs. SD/PR | |||
| CTLA-4 | CD152 | 1.39 | 0.786 |
| PD-1 | CD279 | 1.59 | 0.743 |
| CD45RO | CD45RO | 1.69 | 0.450 |
| BTLA | CD272 | −1.75 | 0.450 |
| CD19 | CD19 | −1.8 | 0.743 |
| HLA-DRA | HLA-DRA | −1.84 | 0.450 |
| CD40 | CD40 | −2.04 | 0.450 |
| Protein namea . | CD name . | FCb . | Adjusted P valuec . |
|---|---|---|---|
| Baseline PD vs. SD/PR | |||
| CTLA-4 | CD152 | 1.8 | 0.388 |
| NCAM | CD56 | 1.66 | 0.388 |
| CD45RO | CD45RO | 1.52 | 0.388 |
| d43 PD vs. SD/PR | |||
| CTLA-4 | CD152 | 1.39 | 0.786 |
| PD-1 | CD279 | 1.59 | 0.743 |
| CD45RO | CD45RO | 1.69 | 0.450 |
| BTLA | CD272 | −1.75 | 0.450 |
| CD19 | CD19 | −1.8 | 0.743 |
| HLA-DRA | HLA-DRA | −1.84 | 0.450 |
| CD40 | CD40 | −2.04 | 0.450 |
NanoString protein profiling was used to test elutriated circulating lymphocytes. n = 16 (at baseline: 1 PR, 6 SD, 9 PD), and n = 11 (at d43: 1 PR, 4 SD, 6 PD). Immune checkpoint molecules are in bold.
Common protein name is listed. CD, cluster of differentiation name. FC, fold change.
Fold change is shown, where positive expression is higher in PD (Bad) compared to SD/PR (good) patient group. Negative correlations are shaded.
False discovery rate adjusted P value was calculated using Benjamini Hochberg correction.