| Antibody . | Binding group . | Protection (%) . | EC50 binding . | EC50 neutralization . | Glycans . | ADNP . | ADCP . |
|---|---|---|---|---|---|---|---|
| MAY-134 | E2: A, C | 100 | 31 (24–47) | 9 (4–13) | G2S2, G2S1, G2S1F, | ++ | ++ |
| G0F, G1F, G2F | |||||||
| MAY-122 | E2: B | 80 | 7 (5–11) | 3 (2–6) | G2S2, G2S1F, G0F, | ++ | + |
| G1F-G1FB, G2F | |||||||
| MAY-133 | E2: A, C | 70 | 27 (21–38) | 25 (14–44) | G2S2, G2S1, G0F, | ++ | ++ |
| G1F-G1FB, G2F | |||||||
| MAY-139 | E2: C | 70 | 18 (9–55) | 246 (133–342) | G2S2, G2S1, G2S1F, G0, | − | − |
| G0F, G1F-G1FB, GIFB-G2, G2F | |||||||
| MAY-125 | E2: B | 60 | 3 (2–8) | 22 (14–42) | G0F, G1F-G1FB, | − | − |
| G1FB-G2, G2F | |||||||
| MAY-140 | E2: A | 0 | 16 (12–22) | 18 (11–30) | G0F, G1F | − | − |
| MAY-115 | E1 | 100 | 2 (1–7) | 2 (1–3) | N/A | N/A | N/A |
| MAY-131 | E1 | 50 | 2 (1–4) | 8 (2–14) | N/A | N/A | N/A |
| Antibody . | Binding group . | Protection (%) . | EC50 binding . | EC50 neutralization . | Glycans . | ADNP . | ADCP . |
|---|---|---|---|---|---|---|---|
| MAY-134 | E2: A, C | 100 | 31 (24–47) | 9 (4–13) | G2S2, G2S1, G2S1F, | ++ | ++ |
| G0F, G1F, G2F | |||||||
| MAY-122 | E2: B | 80 | 7 (5–11) | 3 (2–6) | G2S2, G2S1F, G0F, | ++ | + |
| G1F-G1FB, G2F | |||||||
| MAY-133 | E2: A, C | 70 | 27 (21–38) | 25 (14–44) | G2S2, G2S1, G0F, | ++ | ++ |
| G1F-G1FB, G2F | |||||||
| MAY-139 | E2: C | 70 | 18 (9–55) | 246 (133–342) | G2S2, G2S1, G2S1F, G0, | − | − |
| G0F, G1F-G1FB, GIFB-G2, G2F | |||||||
| MAY-125 | E2: B | 60 | 3 (2–8) | 22 (14–42) | G0F, G1F-G1FB, | − | − |
| G1FB-G2, G2F | |||||||
| MAY-140 | E2: A | 0 | 16 (12–22) | 18 (11–30) | G0F, G1F | − | − |
| MAY-115 | E1 | 100 | 2 (1–7) | 2 (1–3) | N/A | N/A | N/A |
| MAY-131 | E1 | 50 | 2 (1–4) | 8 (2–14) | N/A | N/A | N/A |
IgG2a mAbs that bind to MAYV-E2 (top) or E1 (bottom) are listed along with the mapped binding group, percentage of mice protected from lethal challenge, EC50 values for binding to MAYV-BeH407 infected Vero cells (EC50 binding) at 4°C, neutralization of MAYV-BeH407 (EC50 neutralization), glycan profile, and antibody-dependent neutrophil phagocytosis and antibody-dependent cellular phagocytosis activity. Antibodies are listed in order from most protective to least protective in each class. EC50 values are nanograms per milliliter. ADCP, antibody-dependent cellular phagocytosis; ADNP, antibody-dependent neutrophil phagocytosis; N/A, not applicable.