Table 4. CAMERA statistics used in the... | Rockefeller University Press

Table 4.

CAMERA statistics used in the validation of the Mg-52 and beMφ-50 genetic signatures

GEO dataset	Control	Experimental	Mg-52		beMφ-50
GEO dataset	Control	Experimental	T statistic	FDR	T statistic	FDR

GSE75246	Microglia, vehicle treated	Microglia, LPS treated	−9.18997599139088	8.73894827192082E-20^{^a}	−0.960428754944643	0.336853025380644
GSE75246	Microglia, vehicle treated	Neuron, vehicle treated	−9.28373097503757	3.65539900363888E-20^{^a}	−1.6069073647106	0.108093118311235
GSE75246	Microglia, vehicle treated	Astrocyte, vehicle treated	−8.43449685504562	7.17579519282282E-17^{^a}	−0.982701094445303	0.325768448416933
GSE75246	Microglia, LPS treated	Neuron LPS treated	−5.703178515505	2.3906543497579E-08^{^a}	−1.23253311708603	0.217766916347967
GSE75246	Microglia, LPS treated	Astrocyte, LPS treated	−3.82020514805529	0.000267622477204^{^a}	−0.76323460910686	0.445334000895242
GSE75246	Neuron, vehicle treated	Neuron, LPS treated	−2.48230960173674	0.026125771365367	1.03261170555403	0.30180022362708
GSE75246	Neuron, vehicle treated	Astrocyte, vehicle treated	2.39665178928464	0.033112577014953	0.940103366793486	0.347177795693465
GSE75246	Astrocyte, vehicle treated	Astrocyte, LPS treated	−0.355557598200872	0.722176280064764	−0.55668524588016	0.722176280064764
GSE15907	Microglia	SI LP macrophage	−11.2065064200678	9.18045352544835E-29^{^a}	4.71522334166825	2.43012363462998E-06^{^a}
GSE15907	Microglia	Lung CD11b⁺ macrophage	−17.8986346561823	8.2656485448573E-71^{^a}	3.75505071435236	0.000173778763046^{^a}
GSE15907	Microglia	SI serosal macrophage	−12.8781234055138	1.66788609720075E-37^{^a}	4.98232404004903	6.33293438301929E-07^{^a}
GSE15907	Microglia	Peritoneal F4/80lo macrophage	−13.8346052104306	4.90645664168948E-43^{^a}	1.33690258052763	0.181269070989656
GSE15907	Microglia	LN CD169⁺CD11c⁺ macrophage	−16.7938329111185	1.40723697488701E-62^{^a}	0.323384063567144	0.746407650677293
GSE15907	Microglia	BM macrophage	−14.1038712769937	1.1592597363317E-44^{^a}	−0.91021289075231	0.362720802630218
GSE15907	Microglia	Medullary sinus macrophage	−16.9449218942956	1.12872637834688E-63^{^a}	0.394208861959158	0.693430887937153
GSE15907	Microglia	LN subcapsular macrophage	−16.8108255068152	1.06072069454246E-62^{^a}	−0.569435569747971	0.569066737637983
GSE15907	Microglia	Peritoneal F4/80^hi macrophage	−13.2907475407257	7.64121015322315E-40^{^a}	1.77706541396221	0.075572099377594
GSE15907	Microglia	Red pulp macrophage	−13.8968419518646	2.07736897631509E-43^{^a}	0.800634377157631	0.423352494668722
GSE15907	Microglia	Lung CD11c⁺ macrophage	−12.449942293778	3.74528948133128E-35^{^a}	−1.84381236333192	0.065224715729658
GSE15907	Microglia	BM Ly6c⁺MHCII⁻ monocyte	−15.9185653482659	2.03921322346964E-56^{^a}	−0.818538144350527	0.413059355130746
GSE15907	Microglia	BM Ly6c⁻MHCII⁻ monocyte	−16.995529069284	4.82435079029921E-64^{^a}	−0.4980128606501	0.618480246889288
GSE15907	Microglia	Blood Ly6c⁺MHCII⁺ monocyte	−16.4580514220967	3.54539257686525E-60^{^a}	0.935598972668471	0.349490573927721
GSE15907	Microglia	Blood Ly6c⁺MHCII⁻ monocyte	−13.4521196565583	8.89007050093597E-41^{^a}	0.93218558886987	0.351251449984407
GSE15907	Microglia	LN Ly6c⁺MHCII⁻ monocyte	−16.8225925914844	8.72001502349316E-63^{^a}	1.24084625878423	0.214676554440318
GSE15907	Microglia	Blood Ly6c⁻MHCII⁺ monocyte	−18.884692403881	1.39532275643974E-78^{^a}	0.270993599010383	0.786398646520675
GSE15907	Microglia	Blood Ly6c⁻MHCII⁻ monocyte	−16.5767118715121	5.08670106411122E-61^{^a}	−0.514869830796944	0.60664945933478
GSE15907	Microglia	Blood Ly6c⁻MHCII^int monocyte	−13.856797569651	3.61293182305638E-43^{^a}	0.232110933264168	0.816454138490933
GSE15907	Microglia	Blood neutrophil	−12.9632371395544	5.56623874137407E-38^{^a}	−1.79279030852971	0.073020996049815
GSE15907	Microglia	BM neutrophil	−11.4003953949682	1.02230860670541E-29^{^a}	−1.72096439038072	0.08527216840678
GSE15907	Microglia	Spleen CD4⁺ DC	−13.9384560198774	1.16689659747184E-43^{^a}	−0.245307707479572	0.806220606319135
GSE15907	Microglia	Spleen CD8⁺ DC	−13.7057882876266	2.87179757732365E-42^{^a}	0.398151064886531	0.690522924468198
GSE15907	Microglia	Spleen CD4⁻CD8⁻CD11b⁻ DC	−15.1108056316066	5.1513600603475E-51^{^a}	−0.371877852772889	0.709987586561984
GSE15907	Microglia	Spleen CD8⁺ pDC	−11.9560451648539	1.54734296499501E-32^{^a}	−0.5330479854046	0.594006063116689
GSE15907	Microglia	Spleen CD8⁻ pDC	−12.0888471854728	3.13529730173023E-33^{^a}	−0.686519292990229	0.492393361276459
GSE15907	Microglia	Spleen CD4⁻CD8⁻CD11b⁺ DC	−16.7499579333542	2.91605319710899E-62^{^a}	−0.773651602002031	0.439145647090047
GSE15907	Microglia	Lung CD103⁺ DC	−12.9476715882146	6.80692723941832E-38^{^a}	1.56459587282508	0.117692921772633
GSE15907	Microglia	Lung CD11b⁺CD24⁺ DC	−14.2347565935749	1.83032966037038E-45^{^a}	1.79831123076597	0.072142206176879
GSE15907	Microglia	Liver CD103⁺ DC	−14.59556587753	1.0361250320237E-47^{^a}	0.882871388829489	0.377315974859225
GSE15907	Microglia	Kidney CD103⁻CD11b⁺F4/80^lo DC	−13.3863273878228	2.14353221609188E-40^{^a}	1.96342185139998	0.049610489223897
GSE15907	Microglia	Langerhans cell	−13.5648053990461	1.94992734843495E-41^{^a}	−0.368430279415978	0.71255617554319
GSE15907	Microglia	Spleen follicular B cell	−11.8221570653282	7.60363847464607E-32^{^a}	−2.06435720774193	0.038996239349848
GSE15907	Microglia	Spleen MZ B cell	−12.8680272621344	1.89888380743561E-37^{^a}	−2.21791907042995	0.02657112051891
GSE15907	Microglia	Spleen GC B cell	−11.6270160082023	7.5026540207794E-31^{^a}	−2.63836018619294	0.008337012761183
GSE15907	Microglia	Peritoneal B1a cell	−12.8368524481395	2.83249315683069E-37^{^a}	−2.25999214810576	0.023832043427742
GSE15907	Microglia	Peritoneal B1b cell	−12.4704022163508	2.90329306882604E-35^{^a}	−2.03073615939647	0.042294469723543
GSE15907	Microglia	Spleen naive CD4⁺ T cell	−12.0514689371187	4.92231507926634E-33^{^a}	−1.32085874766837	0.186563009465559
GSE15907	Microglia	Spleen naive CD8⁺ T cell	−15.632336222605	1.79884156914574E-54^{^a}	−1.88247758455911	0.059785157409316
GSE15907	Microglia	Spleen memory CD4⁺ T cell	−12.7721168022034	6.47878151163567E-37^{^a}	−0.442027244316272	0.658474090360188
GSE15907	Microglia	Spleen memory CD8⁺ T cell	−13.5419211345285	2.65618103458737E-41^{^a}	−1.33469326750991	0.181991378524863
GSE15907	Microglia	Spleen T regulatory cell	−15.4254434586749	4.36485159999069E-53^{^a}	−1.26238816488991	0.206823310056597
GSE15907	Microglia	Spleen natural killer cell	−15.8677797159762	4.54101007200768E-56^{^a}	−1.28565291148151	0.198578545975841
GSE68376	Microglia	beMφ	−10.6110235228595	6.8924083456567E-26^{^a}	6.56936921593136	5.25863738290986E-11^{^a}
GSE108575	Microglia, LPS treated	beMφ, LPS treated	−7.64393242343623	2.23315767992962E-14^{^a}	8.126057045216	9.55133453377967E-16^{^a}
GSE99078	iMac, day 0	BM Mac, day 0	−2.27409571243689	0.022973398251917	4.85289376959958	2.45636395979254E-06^{^a}
GSE99078	iMac, day 3	BM Mac, day 3	−5.60231923708091	4.29964257929522E-08^{^a}	1.34724285505885	0.177921083688115
GSE99078	iMac, day 6	BM Mac, day 6	−5.17686685222183	4.56742989186354E-07^{^a}	3.23262604923775	0.001229061186423
GSE99078	iMac, day 12	BM Mac, day 12	−4.26858897016626	2.48966525049818E-05^{^a}	4.21696975941865	2.48966525049818E-05^{^a}

GEO dataset	Control	Experimental	Mg-52		beMφ-50
GEO dataset	Control	Experimental	T statistic	FDR	T statistic	FDR

GSE75246	Microglia, vehicle treated	Microglia, LPS treated	−9.18997599139088	8.73894827192082E-20^{^a}	−0.960428754944643	0.336853025380644
GSE75246	Microglia, vehicle treated	Neuron, vehicle treated	−9.28373097503757	3.65539900363888E-20^{^a}	−1.6069073647106	0.108093118311235
GSE75246	Microglia, vehicle treated	Astrocyte, vehicle treated	−8.43449685504562	7.17579519282282E-17^{^a}	−0.982701094445303	0.325768448416933
GSE75246	Microglia, LPS treated	Neuron LPS treated	−5.703178515505	2.3906543497579E-08^{^a}	−1.23253311708603	0.217766916347967
GSE75246	Microglia, LPS treated	Astrocyte, LPS treated	−3.82020514805529	0.000267622477204^{^a}	−0.76323460910686	0.445334000895242
GSE75246	Neuron, vehicle treated	Neuron, LPS treated	−2.48230960173674	0.026125771365367	1.03261170555403	0.30180022362708
GSE75246	Neuron, vehicle treated	Astrocyte, vehicle treated	2.39665178928464	0.033112577014953	0.940103366793486	0.347177795693465
GSE75246	Astrocyte, vehicle treated	Astrocyte, LPS treated	−0.355557598200872	0.722176280064764	−0.55668524588016	0.722176280064764
GSE15907	Microglia	SI LP macrophage	−11.2065064200678	9.18045352544835E-29^{^a}	4.71522334166825	2.43012363462998E-06^{^a}
GSE15907	Microglia	Lung CD11b⁺ macrophage	−17.8986346561823	8.2656485448573E-71^{^a}	3.75505071435236	0.000173778763046^{^a}
GSE15907	Microglia	SI serosal macrophage	−12.8781234055138	1.66788609720075E-37^{^a}	4.98232404004903	6.33293438301929E-07^{^a}
GSE15907	Microglia	Peritoneal F4/80lo macrophage	−13.8346052104306	4.90645664168948E-43^{^a}	1.33690258052763	0.181269070989656
GSE15907	Microglia	LN CD169⁺CD11c⁺ macrophage	−16.7938329111185	1.40723697488701E-62^{^a}	0.323384063567144	0.746407650677293
GSE15907	Microglia	BM macrophage	−14.1038712769937	1.1592597363317E-44^{^a}	−0.91021289075231	0.362720802630218
GSE15907	Microglia	Medullary sinus macrophage	−16.9449218942956	1.12872637834688E-63^{^a}	0.394208861959158	0.693430887937153
GSE15907	Microglia	LN subcapsular macrophage	−16.8108255068152	1.06072069454246E-62^{^a}	−0.569435569747971	0.569066737637983
GSE15907	Microglia	Peritoneal F4/80^hi macrophage	−13.2907475407257	7.64121015322315E-40^{^a}	1.77706541396221	0.075572099377594
GSE15907	Microglia	Red pulp macrophage	−13.8968419518646	2.07736897631509E-43^{^a}	0.800634377157631	0.423352494668722
GSE15907	Microglia	Lung CD11c⁺ macrophage	−12.449942293778	3.74528948133128E-35^{^a}	−1.84381236333192	0.065224715729658
GSE15907	Microglia	BM Ly6c⁺MHCII⁻ monocyte	−15.9185653482659	2.03921322346964E-56^{^a}	−0.818538144350527	0.413059355130746
GSE15907	Microglia	BM Ly6c⁻MHCII⁻ monocyte	−16.995529069284	4.82435079029921E-64^{^a}	−0.4980128606501	0.618480246889288
GSE15907	Microglia	Blood Ly6c⁺MHCII⁺ monocyte	−16.4580514220967	3.54539257686525E-60^{^a}	0.935598972668471	0.349490573927721
GSE15907	Microglia	Blood Ly6c⁺MHCII⁻ monocyte	−13.4521196565583	8.89007050093597E-41^{^a}	0.93218558886987	0.351251449984407
GSE15907	Microglia	LN Ly6c⁺MHCII⁻ monocyte	−16.8225925914844	8.72001502349316E-63^{^a}	1.24084625878423	0.214676554440318
GSE15907	Microglia	Blood Ly6c⁻MHCII⁺ monocyte	−18.884692403881	1.39532275643974E-78^{^a}	0.270993599010383	0.786398646520675
GSE15907	Microglia	Blood Ly6c⁻MHCII⁻ monocyte	−16.5767118715121	5.08670106411122E-61^{^a}	−0.514869830796944	0.60664945933478
GSE15907	Microglia	Blood Ly6c⁻MHCII^int monocyte	−13.856797569651	3.61293182305638E-43^{^a}	0.232110933264168	0.816454138490933
GSE15907	Microglia	Blood neutrophil	−12.9632371395544	5.56623874137407E-38^{^a}	−1.79279030852971	0.073020996049815
GSE15907	Microglia	BM neutrophil	−11.4003953949682	1.02230860670541E-29^{^a}	−1.72096439038072	0.08527216840678
GSE15907	Microglia	Spleen CD4⁺ DC	−13.9384560198774	1.16689659747184E-43^{^a}	−0.245307707479572	0.806220606319135
GSE15907	Microglia	Spleen CD8⁺ DC	−13.7057882876266	2.87179757732365E-42^{^a}	0.398151064886531	0.690522924468198
GSE15907	Microglia	Spleen CD4⁻CD8⁻CD11b⁻ DC	−15.1108056316066	5.1513600603475E-51^{^a}	−0.371877852772889	0.709987586561984
GSE15907	Microglia	Spleen CD8⁺ pDC	−11.9560451648539	1.54734296499501E-32^{^a}	−0.5330479854046	0.594006063116689
GSE15907	Microglia	Spleen CD8⁻ pDC	−12.0888471854728	3.13529730173023E-33^{^a}	−0.686519292990229	0.492393361276459
GSE15907	Microglia	Spleen CD4⁻CD8⁻CD11b⁺ DC	−16.7499579333542	2.91605319710899E-62^{^a}	−0.773651602002031	0.439145647090047
GSE15907	Microglia	Lung CD103⁺ DC	−12.9476715882146	6.80692723941832E-38^{^a}	1.56459587282508	0.117692921772633
GSE15907	Microglia	Lung CD11b⁺CD24⁺ DC	−14.2347565935749	1.83032966037038E-45^{^a}	1.79831123076597	0.072142206176879
GSE15907	Microglia	Liver CD103⁺ DC	−14.59556587753	1.0361250320237E-47^{^a}	0.882871388829489	0.377315974859225
GSE15907	Microglia	Kidney CD103⁻CD11b⁺F4/80^lo DC	−13.3863273878228	2.14353221609188E-40^{^a}	1.96342185139998	0.049610489223897
GSE15907	Microglia	Langerhans cell	−13.5648053990461	1.94992734843495E-41^{^a}	−0.368430279415978	0.71255617554319
GSE15907	Microglia	Spleen follicular B cell	−11.8221570653282	7.60363847464607E-32^{^a}	−2.06435720774193	0.038996239349848
GSE15907	Microglia	Spleen MZ B cell	−12.8680272621344	1.89888380743561E-37^{^a}	−2.21791907042995	0.02657112051891
GSE15907	Microglia	Spleen GC B cell	−11.6270160082023	7.5026540207794E-31^{^a}	−2.63836018619294	0.008337012761183
GSE15907	Microglia	Peritoneal B1a cell	−12.8368524481395	2.83249315683069E-37^{^a}	−2.25999214810576	0.023832043427742
GSE15907	Microglia	Peritoneal B1b cell	−12.4704022163508	2.90329306882604E-35^{^a}	−2.03073615939647	0.042294469723543
GSE15907	Microglia	Spleen naive CD4⁺ T cell	−12.0514689371187	4.92231507926634E-33^{^a}	−1.32085874766837	0.186563009465559
GSE15907	Microglia	Spleen naive CD8⁺ T cell	−15.632336222605	1.79884156914574E-54^{^a}	−1.88247758455911	0.059785157409316
GSE15907	Microglia	Spleen memory CD4⁺ T cell	−12.7721168022034	6.47878151163567E-37^{^a}	−0.442027244316272	0.658474090360188
GSE15907	Microglia	Spleen memory CD8⁺ T cell	−13.5419211345285	2.65618103458737E-41^{^a}	−1.33469326750991	0.181991378524863
GSE15907	Microglia	Spleen T regulatory cell	−15.4254434586749	4.36485159999069E-53^{^a}	−1.26238816488991	0.206823310056597
GSE15907	Microglia	Spleen natural killer cell	−15.8677797159762	4.54101007200768E-56^{^a}	−1.28565291148151	0.198578545975841
GSE68376	Microglia	beMφ	−10.6110235228595	6.8924083456567E-26^{^a}	6.56936921593136	5.25863738290986E-11^{^a}
GSE108575	Microglia, LPS treated	beMφ, LPS treated	−7.64393242343623	2.23315767992962E-14^{^a}	8.126057045216	9.55133453377967E-16^{^a}
GSE99078	iMac, day 0	BM Mac, day 0	−2.27409571243689	0.022973398251917	4.85289376959958	2.45636395979254E-06^{^a}
GSE99078	iMac, day 3	BM Mac, day 3	−5.60231923708091	4.29964257929522E-08^{^a}	1.34724285505885	0.177921083688115
GSE99078	iMac, day 6	BM Mac, day 6	−5.17686685222183	4.56742989186354E-07^{^a}	3.23262604923775	0.001229061186423
GSE99078	iMac, day 12	BM Mac, day 12	−4.26858897016626	2.48966525049818E-05^{^a}	4.21696975941865	2.48966525049818E-05^{^a}

Publically available transcriptomic datasets and transcriptomic data generated in the current study were used to assess for enrichment of Mg-52 and beMφ-50 gene signatures. CAMERA analysis was performed as described in Materials and methods.

Significance threshold FDR <0.001.

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