Table 1. Summary of immunodeficient mice... | Rockefeller University Press

Table 1.

Summary of immunodeficient mice useful in human hematopoietic xenograft studies

Strain name	Common name	Mutant alleles	Phenotype	HSC engraftment	Leukemic engraftment (AML/ALL)	References
B6.CB17-Prkdc^scid/Szj	SCID	Prkdc^scid	Leaky immunodeficient	+	+/+	Bosma et al., 1983; McCune et al., 1988; Mosier et al., 1988; Fulop and Phillips, 1990; Lapidot et al., 1992; Greiner et al., 1998
B6.129S7-Rag1^tm1Mom/J	Rag1KO	Rag1^tm1Mom	Nonleaky immunodeficient	+	+/+	Mombaerts et al., 1992; Shinkai et al., 1993; Greiner et al., 1998
B6(Cg)-Rag2^tm1.1Cgn/J	Rag2KO	Rag2^tm1.1Cgn	Nonleaky immunodeficient	+	+/+	Mombaerts et al., 1992; Shinkai et al., 1992; Greiner et al., 1998
NOD.CB17-Prkdc^scid/J	NOD-SCID	Hc⁰; Prkdc^scid	NOD immunodeficient	+	+/+	Hesselton et al., 1995; Lowry et al., 1996; Pflumio et al., 1996
NOD.129P2(B6)-B2m^tm1Unc/J	NOD/B2M	B2m^tm1Unc	NOD, MHC class I negative	+	+/+	Koller et al., 1990; Feuring-Buske et al., 2003
B6.129S4-Il2rg^tm1Wjl/J	IL-2Rγ^null	Il2rg^tm1Wjl	T/B/natural killer cell deficient	+	Not assessed	Cao et al., 1995
C.Cg-Rag2^tm1FwaIl2rg^tm1Sug	BRG	Rag2^tm1Fwa; Il2rg^tm1Sug	BALB/c, immunodeficient, radiosensitive, humanized	++	Not assessed	Traggiai et al., 2004
NOD.cg-Prkdc^scidIl2rg^tm1Sug	NOG	Prkdc^scid; Il2rg^tm1Sug	NOD, immunodeficient, radiosensitive, humanized	++	++/++	Ito et al., 2002; Yahata et al., 2003
NOD.Cg-Rag1^tm1MomIl2rg^tm1Wjl	NRG	Rag1^tm1Mom; Il2rg^tm1Wjl	NOD, immunodeficient, radiosensitive, humanized	+++	+++/++	Pearson et al., 2008; Brehm et al., 2010; Maykel et al., 2014
NOD.Cg-Prkdc^scidIl2rg^tm1Wjl	NSG	Prkdc^scid; Il2rg^tm1Wjl	NOD, immunodeficient, radiosensitive, humanized	+++	+++/++	Ito et al., 2002; Traggiai et al., 2004; Ishikawa et al., 2005; Shultz et al., 2005
NOD.Cg-Prkdc^scidIl2rg^tm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ	NSG-SGM3; NSGS	Prkdc^scid; Il2rg^tm1Wjl; Tg(CMV-IL3,CSF2,KITLG)1Eav	NOD, immunodeficient, radiosensitive, humanized; expresses 3 human cytokines	+++	++++/+++	Nicolini et al., 2004; Wunderlich et al., 2010; Takagi et al., 2012; Yoshimi et al., 2017
C;129S4-Rag2^tm1.FlvCsf1^tm1(CSF1)FlvCsf2lIl3^{tm1.1(CSF2,IL3)Flv}Thpo^{tm1.1(TPO)Flv}Il2rg^tm1.1Flv/J	MITRG	Rag2^tm1.Flv; Csf1^tm1(CSF1)Flv; Csf2lIl3^{tm1.1(CSF2,IL3)Flv};Thpo^{tm1.1(TPO)Flv}; Il2rg^tm1.1Flv	Immunodeficient, humanized; expresses 3 human cytokines	+++	++++/not assessed	Rongvaux et al., 2014; Ellegast et al., 2016
C;129S4-Rag2^tm1.1Flv Csf1^tm1(CSF1)Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv Tg(SIRPA)1Flv/J	MISTRG	Rag2^tm1.1Flv Csf1^tm1(CSF1)Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv Tg(SIRPA)1Flv	Immunodeficient, humanized; expresses 4 human cytokines	+++	++++/not assessed	Rongvaux et al., 2014 ;Das et al., 2016 ; Ellegast et al., 2016
NOD.Cg-Kit^W-41J Prkdc^scid Il2rg^tm1Wjl/WaskJ	NSGW41	Kit^W-41J; Prkdc^scid ; Il2rg^tm1Wjl	NOD, immunodeficient, humanized, human engraftment without irradiation	+++	Not assessed	Cosgun et al., 2014
NOD.Cg-Kit^W-41J Tyr ⁺ Prkdc^scid Il2rg^tm1Wjl/ThomJ	NBSGW	Kit^W-41J; Tyr ⁺; Prkdc^scid ; Il2rg^tm1Wjl	NOD, immunodeficient, humanized, human engraftment without irradiation	+++	Not assessed	McIntosh and Brown, 2015
C57BL/6 Rag2^null Il2rg^null NOD-Sirpa Kit^Wv/Wv	BRGSK	Rag2^null;Il2rg^null;Kit^Wv/Wv	NOD, immunodeficient, humanized, human engraftment without irradiation	+++	Not assessed	Yurino et al., 2016
NOD.Cg-Foxn1^em1Dvs Prkdc^scid Il2rg^tm1Wjl/J	NSG-nude	Foxn1^em1Dvs ;Prkdc^scid ;Il2rg^tm1Wjl	NOD, immunodeficient, radiosensitive, humanized, hairless	Not assessed	Not assessed/+++	Wei et al., 2017

Strain name	Common name	Mutant alleles	Phenotype	HSC engraftment	Leukemic engraftment (AML/ALL)	References
B6.CB17-Prkdc^scid/Szj	SCID	Prkdc^scid	Leaky immunodeficient	+	+/+	Bosma et al., 1983; McCune et al., 1988; Mosier et al., 1988; Fulop and Phillips, 1990; Lapidot et al., 1992; Greiner et al., 1998
B6.129S7-Rag1^tm1Mom/J	Rag1KO	Rag1^tm1Mom	Nonleaky immunodeficient	+	+/+	Mombaerts et al., 1992; Shinkai et al., 1993; Greiner et al., 1998
B6(Cg)-Rag2^tm1.1Cgn/J	Rag2KO	Rag2^tm1.1Cgn	Nonleaky immunodeficient	+	+/+	Mombaerts et al., 1992; Shinkai et al., 1992; Greiner et al., 1998
NOD.CB17-Prkdc^scid/J	NOD-SCID	Hc⁰; Prkdc^scid	NOD immunodeficient	+	+/+	Hesselton et al., 1995; Lowry et al., 1996; Pflumio et al., 1996
NOD.129P2(B6)-B2m^tm1Unc/J	NOD/B2M	B2m^tm1Unc	NOD, MHC class I negative	+	+/+	Koller et al., 1990; Feuring-Buske et al., 2003
B6.129S4-Il2rg^tm1Wjl/J	IL-2Rγ^null	Il2rg^tm1Wjl	T/B/natural killer cell deficient	+	Not assessed	Cao et al., 1995
C.Cg-Rag2^tm1FwaIl2rg^tm1Sug	BRG	Rag2^tm1Fwa; Il2rg^tm1Sug	BALB/c, immunodeficient, radiosensitive, humanized	++	Not assessed	Traggiai et al., 2004
NOD.cg-Prkdc^scidIl2rg^tm1Sug	NOG	Prkdc^scid; Il2rg^tm1Sug	NOD, immunodeficient, radiosensitive, humanized	++	++/++	Ito et al., 2002; Yahata et al., 2003
NOD.Cg-Rag1^tm1MomIl2rg^tm1Wjl	NRG	Rag1^tm1Mom; Il2rg^tm1Wjl	NOD, immunodeficient, radiosensitive, humanized	+++	+++/++	Pearson et al., 2008; Brehm et al., 2010; Maykel et al., 2014
NOD.Cg-Prkdc^scidIl2rg^tm1Wjl	NSG	Prkdc^scid; Il2rg^tm1Wjl	NOD, immunodeficient, radiosensitive, humanized	+++	+++/++	Ito et al., 2002; Traggiai et al., 2004; Ishikawa et al., 2005; Shultz et al., 2005
NOD.Cg-Prkdc^scidIl2rg^tm1WjlTg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ	NSG-SGM3; NSGS	Prkdc^scid; Il2rg^tm1Wjl; Tg(CMV-IL3,CSF2,KITLG)1Eav	NOD, immunodeficient, radiosensitive, humanized; expresses 3 human cytokines	+++	++++/+++	Nicolini et al., 2004; Wunderlich et al., 2010; Takagi et al., 2012; Yoshimi et al., 2017
C;129S4-Rag2^tm1.FlvCsf1^tm1(CSF1)FlvCsf2lIl3^{tm1.1(CSF2,IL3)Flv}Thpo^{tm1.1(TPO)Flv}Il2rg^tm1.1Flv/J	MITRG	Rag2^tm1.Flv; Csf1^tm1(CSF1)Flv; Csf2lIl3^{tm1.1(CSF2,IL3)Flv};Thpo^{tm1.1(TPO)Flv}; Il2rg^tm1.1Flv	Immunodeficient, humanized; expresses 3 human cytokines	+++	++++/not assessed	Rongvaux et al., 2014; Ellegast et al., 2016
C;129S4-Rag2^tm1.1Flv Csf1^tm1(CSF1)Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv Tg(SIRPA)1Flv/J	MISTRG	Rag2^tm1.1Flv Csf1^tm1(CSF1)Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv Tg(SIRPA)1Flv	Immunodeficient, humanized; expresses 4 human cytokines	+++	++++/not assessed	Rongvaux et al., 2014 ;Das et al., 2016 ; Ellegast et al., 2016
NOD.Cg-Kit^W-41J Prkdc^scid Il2rg^tm1Wjl/WaskJ	NSGW41	Kit^W-41J; Prkdc^scid ; Il2rg^tm1Wjl	NOD, immunodeficient, humanized, human engraftment without irradiation	+++	Not assessed	Cosgun et al., 2014
NOD.Cg-Kit^W-41J Tyr ⁺ Prkdc^scid Il2rg^tm1Wjl/ThomJ	NBSGW	Kit^W-41J; Tyr ⁺; Prkdc^scid ; Il2rg^tm1Wjl	NOD, immunodeficient, humanized, human engraftment without irradiation	+++	Not assessed	McIntosh and Brown, 2015
C57BL/6 Rag2^null Il2rg^null NOD-Sirpa Kit^Wv/Wv	BRGSK	Rag2^null;Il2rg^null;Kit^Wv/Wv	NOD, immunodeficient, humanized, human engraftment without irradiation	+++	Not assessed	Yurino et al., 2016
NOD.Cg-Foxn1^em1Dvs Prkdc^scid Il2rg^tm1Wjl/J	NSG-nude	Foxn1^em1Dvs ;Prkdc^scid ;Il2rg^tm1Wjl	NOD, immunodeficient, radiosensitive, humanized, hairless	Not assessed	Not assessed/+++	Wei et al., 2017