| Gene . | Mouse model . | Phenotype . | Reference . |
|---|---|---|---|
| GATA2 | GATA2ΔCF | Loss of mast cell phenotype in BMMCs | Ohmori et al., 2015 |
| STAT5 | STAT5A/B +/− | Deficiency of mast cells in all analyzed tissues | Shelburne et al., 2003 |
| MITF | MITF −/− (tg/tg mice) | Deficiency of mast cells in peritoneum, mesentery, stomach, spleen | Morii et al., 2004 |
| NDST2 | NDST2 −/− | Decreased numbers of connective tissue mast cells and reduced mast cell proteases and histamine content | Forsberg et al., 1999 |
| HDC | HDC −/− mice | Decreased numbers of peritoneal and mesenterial mast cells and decreased histamine content | Ohtsu et al., 2001 |
| CPA3 | CPA3 −/− mice | Immature peritoneal mast cells with reduced granular staining | Feyerabend et al., 2005 |
| PI3K | p85α −/− and p110γ −/− DKO mice | Severe defects in mast cell development | Takayama et al., 2013 |
| PI3K | p85α −/− mice | Mast cell deficiency in gastrointestinal and peritoneal mast cells | Fukao et al., 2002 |
| AHR | AHR −/− mice | Reduction in skin, peritoneal cavity, and stomach mucosa–resident mast cells | Zhou et al., 2013 |
| SRGN | SRGN −/− mice | Deficiency in granulated mast cells in peritoneum and ear | Åbrink et al., 2004 |
| PLA2G3 | PLA2G3 −/− mice | Irregularly shaped and immature tissue mast cells | Taketomi et al., 2013 |
| Mac-1 (CD11b/CD18, CR3) | Mac-1 −/− mice | Decreased number of mast cells in peritoneum and dorsal epidermis | Rosenkranz et al., 1998 |
| P38α | Mx-Cre+ P38αF/F (P38α−/−) | Decreased numbers of peritoneal and lung mast cells | Hu et al., 2012 |
| Gene . | Mouse model . | Phenotype . | Reference . |
|---|---|---|---|
| GATA2 | GATA2ΔCF | Loss of mast cell phenotype in BMMCs | Ohmori et al., 2015 |
| STAT5 | STAT5A/B +/− | Deficiency of mast cells in all analyzed tissues | Shelburne et al., 2003 |
| MITF | MITF −/− (tg/tg mice) | Deficiency of mast cells in peritoneum, mesentery, stomach, spleen | Morii et al., 2004 |
| NDST2 | NDST2 −/− | Decreased numbers of connective tissue mast cells and reduced mast cell proteases and histamine content | Forsberg et al., 1999 |
| HDC | HDC −/− mice | Decreased numbers of peritoneal and mesenterial mast cells and decreased histamine content | Ohtsu et al., 2001 |
| CPA3 | CPA3 −/− mice | Immature peritoneal mast cells with reduced granular staining | Feyerabend et al., 2005 |
| PI3K | p85α −/− and p110γ −/− DKO mice | Severe defects in mast cell development | Takayama et al., 2013 |
| PI3K | p85α −/− mice | Mast cell deficiency in gastrointestinal and peritoneal mast cells | Fukao et al., 2002 |
| AHR | AHR −/− mice | Reduction in skin, peritoneal cavity, and stomach mucosa–resident mast cells | Zhou et al., 2013 |
| SRGN | SRGN −/− mice | Deficiency in granulated mast cells in peritoneum and ear | Åbrink et al., 2004 |
| PLA2G3 | PLA2G3 −/− mice | Irregularly shaped and immature tissue mast cells | Taketomi et al., 2013 |
| Mac-1 (CD11b/CD18, CR3) | Mac-1 −/− mice | Decreased number of mast cells in peritoneum and dorsal epidermis | Rosenkranz et al., 1998 |
| P38α | Mx-Cre+ P38αF/F (P38α−/−) | Decreased numbers of peritoneal and lung mast cells | Hu et al., 2012 |