Table 1. Immunological findings among... | Rockefeller University Press

Table 1.

Immunological findings among ERBB2IP^mut individuals

	Cell counts			Serum Ig				Antibody titers		Lymphocyte subsets						Serum tryptase
										CD4⁺		CD8⁺		CD20⁺
	ALC	ANC	AEC	IgG	IgA	IgM	IgE	Tetanus	Pneumococcus	Total	Memory^{^a}	Total	Memory^{^a}	Total	Memory^{^b}
	cells/µL	cells/µL	cells/µL	mg/dL	mg/dL	mg/dL	IU/ml	IU/ml	>1.3 µg/ml	cells/µl	%	cells/µl	%	cells/µl	%	ng/ml
Ref.	1,320– 3,570	1,780– 5,380	40–540	700– 1,600	91–499	34–342	0–90	>0.15	16/23	359– 1,565	13–50	178–853	3–16	59–329	0.8–3.6	<11.4
14-y M	3,290– 4,550^{^c}	1,430– 2,410	520– 2,880	368– 898	16–51	45–115	333–898	2.21	21/23	1,670	7.2	952	2	438	1.5	5.3
11-y F	4,450– 7,720^{^c}	1,410– 1,860	90–680	693–737	68–89	90–102	10–98	0.35	20/23	2,506	9	1,501	5.1	794	3.4	4.2
43-y M	2,060–3,010	1,810–4,290	80–310	946–1,290	137–194	55–82	20–200	1.62	13/23	1,457	20	461	5.5	381	1.7	5.2

	Cell counts			Serum Ig				Antibody titers		Lymphocyte subsets						Serum tryptase
										CD4⁺		CD8⁺		CD20⁺
	ALC	ANC	AEC	IgG	IgA	IgM	IgE	Tetanus	Pneumococcus	Total	Memory^{^a}	Total	Memory^{^a}	Total	Memory^{^b}
	cells/µL	cells/µL	cells/µL	mg/dL	mg/dL	mg/dL	IU/ml	IU/ml	>1.3 µg/ml	cells/µl	%	cells/µl	%	cells/µl	%	ng/ml
Ref.	1,320– 3,570	1,780– 5,380	40–540	700– 1,600	91–499	34–342	0–90	>0.15	16/23	359– 1,565	13–50	178–853	3–16	59–329	0.8–3.6	<11.4
14-y M	3,290– 4,550^{^c}	1,430– 2,410	520– 2,880	368– 898	16–51	45–115	333–898	2.21	21/23	1,670	7.2	952	2	438	1.5	5.3
11-y F	4,450– 7,720^{^c}	1,410– 1,860	90–680	693–737	68–89	90–102	10–98	0.35	20/23	2,506	9	1,501	5.1	794	3.4	4.2
43-y M	2,060–3,010	1,810–4,290	80–310	946–1,290	137–194	55–82	20–200	1.62	13/23	1,457	20	461	5.5	381	1.7	5.2

Abbreviations used: AEC, absolute eosinophil count; ALC, absolute lymphocyte count; ANC, absolute neutrophil count; F, female; M, male; Ref., reference range; y, year old.

T cell memory was defined as CD45RO⁺.

B cell memory was defined as CD27⁺.

Increased total lymphocyte counts and reduced memory populations relative to adult reference values are a result of the young age of these individuals and do not represent defective memory formation or other pathology.

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