| . | mtHtt staining . | 4-HNE staining . |
|---|---|---|
| Muscle | ||
| WT TAT | 80.8 ± 2.0 | 45.1 ± 2.8 |
| WT P110 | 94.8 ± 0.5 | |
| R6/2 TAT | 143.3 ± 0.4a | 91.8 ± 2.5b |
| R6/2 P110 | 57.1 ± 0.6c | |
| Skin | ||
| WT TAT | 96.4 ± 4.2 | 95.3 ± 2.8 |
| WT P110 | 89.4 ± 3.3 | |
| R6/2 TAT | 141 ± 5.0d | 148.6 ± 7.0e |
| R6/2 P110 | 85.7 ± 3.5f |
| . | mtHtt staining . | 4-HNE staining . |
|---|---|---|
| Muscle | ||
| WT TAT | 80.8 ± 2.0 | 45.1 ± 2.8 |
| WT P110 | 94.8 ± 0.5 | |
| R6/2 TAT | 143.3 ± 0.4a | 91.8 ± 2.5b |
| R6/2 P110 | 57.1 ± 0.6c | |
| Skin | ||
| WT TAT | 96.4 ± 4.2 | 95.3 ± 2.8 |
| WT P110 | 89.4 ± 3.3 | |
| R6/2 TAT | 141 ± 5.0d | 148.6 ± 7.0e |
| R6/2 P110 | 85.7 ± 3.5f |
Quantification of images of mtHtt and 4-HNE staining in muscle and skin. Images of the respective staining were obtained from three mice/group, and 16 areas of each section were analyzed. 58 areas of each section were analyzed for mtHtt staining in muscle. Data are presented as mean ± SEM.
P = 0.038 (WT TAT vs. R6/2 TAT)
P = 0.0026 (WT TAT vs. R6/2 TAT)
P = 0.027 (R6/2 TAT vs. R6/2 P110)
P = 0.019 (WT TAT vs. R6/2 TAT)
P = 0.018 (WT TAT vs. R6/2 TAT)
P = 0.015 (R6/2 TAT vs. R6/2 P110)