| Promote innate immunity . | ||
|---|---|---|
| Local inflammation | Local irradiation | Liu et al., 2018 |
| Oncolytic viruses | Raja et al., 2018 | |
| Macrophage/DC activation | CD40 | Vonderheide, 2018 |
| TLR or RLR agonists | Li et al., 2017 | |
| Pro-inflammatory cytokines | IFNα | Medrano et al., 2017 |
| Promote phagocytosis | CD47/SIRPα | Liu et al., 2017 |
| Vaccination | DC vaccination | Palucka and Banchereau, 2013 |
| Peptide vaccination | Kumai et al., 2017 | |
| Tumor cell vaccination | Srivatsan et al., 2014 | |
| Promote adaptive immunity | ||
| Induction of tertiary lymphoid structures | LIGHT | Johansson-Percival et al., 2017 |
| Costimulatory agents | CD40, CD137, GITR, ICOS, OX40 | Dempke et al., 2017 |
| T cell activation | IL-2 | Jiang et al., 2016 |
| Pegylated IL-10 | Naing et al., 2018 | |
| STING | Rivera Vargas et al., 2017 | |
| Inhibition of immunosuppression | ||
| ICB | CTLA-4, PD-1/PD-L1 | Seidel et al., 2018 |
| IDO, KIR, LAG-3, Tim-3, VISTA | Dempke et al., 2017 | |
| TAM reprogramming | BTK | Gunderson et al., 2016 |
| Class IIa HDAC | Guerriero et al., 2017 | |
| CD40 | Majety et al., 2018 | |
| Blocking immunosuppressive cytokines | TGFβ | Haque and Morris, 2017 |
| Promote innate immunity . | ||
|---|---|---|
| Local inflammation | Local irradiation | Liu et al., 2018 |
| Oncolytic viruses | Raja et al., 2018 | |
| Macrophage/DC activation | CD40 | Vonderheide, 2018 |
| TLR or RLR agonists | Li et al., 2017 | |
| Pro-inflammatory cytokines | IFNα | Medrano et al., 2017 |
| Promote phagocytosis | CD47/SIRPα | Liu et al., 2017 |
| Vaccination | DC vaccination | Palucka and Banchereau, 2013 |
| Peptide vaccination | Kumai et al., 2017 | |
| Tumor cell vaccination | Srivatsan et al., 2014 | |
| Promote adaptive immunity | ||
| Induction of tertiary lymphoid structures | LIGHT | Johansson-Percival et al., 2017 |
| Costimulatory agents | CD40, CD137, GITR, ICOS, OX40 | Dempke et al., 2017 |
| T cell activation | IL-2 | Jiang et al., 2016 |
| Pegylated IL-10 | Naing et al., 2018 | |
| STING | Rivera Vargas et al., 2017 | |
| Inhibition of immunosuppression | ||
| ICB | CTLA-4, PD-1/PD-L1 | Seidel et al., 2018 |
| IDO, KIR, LAG-3, Tim-3, VISTA | Dempke et al., 2017 | |
| TAM reprogramming | BTK | Gunderson et al., 2016 |
| Class IIa HDAC | Guerriero et al., 2017 | |
| CD40 | Majety et al., 2018 | |
| Blocking immunosuppressive cytokines | TGFβ | Haque and Morris, 2017 |
DC, dendritic cell; ICOS, inducible costimulator; IDO, indoleamine (2,3)-dioxygenase; KIR, killer cell immunoglobulin-like receptor; RLR, RIG-I-like receptor.