| Analysis . | HR (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age ≥65 yr | 0.48 (0.22–1.05) | 0.068 |
| Sex, male | 0.50 (0.24–1.06) | 0.071 |
| III–IV Rai stage | 1.30 (0.56–3.03) | 0.548 |
| Therapy, RR status | 3.14 (1.09–9.01) | 0.034 |
| WBC count | 1.00 (1.00–1.00) | 0.364 |
| β2M ≥4 mg/L | 1.06 (0.43–2.62) | 0.894 |
| CD49d+ | 3.32 (1.35–8.17) | 0.009 |
| UM IGHV | 5.48 (1.65–18.17) | 0.006 |
| TP53 disrupted | 2.71 (1.14–6.43) | 0.025 |
| Del11q | 0.52 (0.16–1.74) | 0.291 |
| Multivariate analysis | ||
| Model 1 | ||
| CD49d+ | 3.15 (1.16–8.53) | 0.025 |
| UM IGHV | 4.17 (1.23–14.15) | 0.023 |
| TP53 disrupted | 2.83 (1.18–6.82) | 0.021 |
| Model 2 | ||
| CD49d+ | 2.61 (1.03–6.61) | 0.043 |
| UM IGHV | 4.32 (1.26–14.81) | 0.020 |
| Therapy, RR status | 1.53 (0.50–4.65) | 0.457 |
| Model 3 | ||
| CD49d+ | 2.61 (0.95–7.16) | 0.065 |
| TP53 disrupted | 3.00 (1.24–7.29) | 0.016 |
| Therapy, RR status | 3.71 (0.83–16.59) | 0.087 |
| Analysis . | HR (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age ≥65 yr | 0.48 (0.22–1.05) | 0.068 |
| Sex, male | 0.50 (0.24–1.06) | 0.071 |
| III–IV Rai stage | 1.30 (0.56–3.03) | 0.548 |
| Therapy, RR status | 3.14 (1.09–9.01) | 0.034 |
| WBC count | 1.00 (1.00–1.00) | 0.364 |
| β2M ≥4 mg/L | 1.06 (0.43–2.62) | 0.894 |
| CD49d+ | 3.32 (1.35–8.17) | 0.009 |
| UM IGHV | 5.48 (1.65–18.17) | 0.006 |
| TP53 disrupted | 2.71 (1.14–6.43) | 0.025 |
| Del11q | 0.52 (0.16–1.74) | 0.291 |
| Multivariate analysis | ||
| Model 1 | ||
| CD49d+ | 3.15 (1.16–8.53) | 0.025 |
| UM IGHV | 4.17 (1.23–14.15) | 0.023 |
| TP53 disrupted | 2.83 (1.18–6.82) | 0.021 |
| Model 2 | ||
| CD49d+ | 2.61 (1.03–6.61) | 0.043 |
| UM IGHV | 4.32 (1.26–14.81) | 0.020 |
| Therapy, RR status | 1.53 (0.50–4.65) | 0.457 |
| Model 3 | ||
| CD49d+ | 2.61 (0.95–7.16) | 0.065 |
| TP53 disrupted | 3.00 (1.24–7.29) | 0.016 |
| Therapy, RR status | 3.71 (0.83–16.59) | 0.087 |
White blood cell count was considered as continuous variable. β2M, β2 microglobulin; CI, confidence interval; Del11q, according to Döhner et al. (2000); HR, hazard ratio; RR, relapsed-refractory; UM, unmutated; WBC, white blood cell.