Table 1.
Characteristics of AML specimens
Sample numberAge/ sexDiagnosisSample typeMolecularChromosomal abnormalitiesFold change in IL1RAP MFI (relative to isotype)
MDS01 60/M High risk MDS PB N/A Monosomy 7 5.9 
MDS02 N/A High risk MDS PB N/A Monosomy 7 7.1 
AML01 76/M AML M4, myelomonocytic BM U2AF1 S34F; TET2 frameshift & C1378Y & D1587G; ASXL1 L1304V; NRAS G13D None detected 10.4 
AML02 68/M Residual AML after induction therapy with monocytic differentiation; history of MPD, DLBCL PB JAK2; SRSF2 P95H; TET2 R550X; TP53 R175H Complex cytogenetics & t(4:11) 6.1 
AML03 High risk MDS/AML PB N/A del(13)(q12q22) and der(18)t(13;18)(q22;q23) 11.8 
AML04 25/M AML M2 BM FLT3-ITD Trisomy 8 4.4 
AML05 62/F AML/MPN PB JAK2 V617F; TP53 R248W; IDH2 R140Q None detected 5.9 
AML06 49/F Relapsed AML PB FLT3-ITD 46,XX 29 
AML07 73/M AML PB N/A 46,XY,t(1;4)(p21;q21)[3]/ 46,XY[7] 4.1 
AML08 70/M AML (monocytic) PB ASXL1 L823* (nonsense); BCOR R1183*; RUNX1 frameshift; SRSF2 P95H; TET2 insertion & R1516* None detected 10.3 
AML09 54/F AML (monocytic) PB FLT3-TKD; DNMT3A R882H; IDH1 R132H; MLL-PTD None detected 22 
AML10 61/F AML M5 with hyperleucocytosis BM FLT3-ITD; DNMT3A R882H; NPM1 frameshift None detected 12 
AML11 48/F AML (monocytic) PB CEBPA frameshift; CSF3R R698H; NF1 SNP None detected 2.5 
AML12 37/F AML PB FLT3-ITD 47,XX,+8[15]/ 46,XX[5] 21–24% trisomy 8 (D8Z2,RUNX1T1)x3[42-48/200] 1.9 
AML13 67/M AML PB MLL-PTD Trisomy 8 13.2 
AML14 59/F AML PB FLT3-ITD; NPM1; WT1 None detected 3.1 
AML15 38/M AML PB NRAS 46,XY t(9;11)(p22;q23) 3.6 
AML16 54/M AML PB DNMT3A, NPM1 None detected 12.7 
AML17 38/M AML PB N/A N/A 8.3 
AML18 29/M AML BM None detected t(8;21)(q22;q22) 45,X,-Y,t(8;21)(q22;q22)[20] 19.4 
AML19 61/M MDS/MPN/AML PB JAK2 46,XY,der(8) ?t(8;21)(q22;q22), del(9)(q13q22), dup(12)(q14q24.1), -22,+1-2mar[8]/46,xy(3) N/A 
Sample numberAge/ sexDiagnosisSample typeMolecularChromosomal abnormalitiesFold change in IL1RAP MFI (relative to isotype)
MDS01 60/M High risk MDS PB N/A Monosomy 7 5.9 
MDS02 N/A High risk MDS PB N/A Monosomy 7 7.1 
AML01 76/M AML M4, myelomonocytic BM U2AF1 S34F; TET2 frameshift & C1378Y & D1587G; ASXL1 L1304V; NRAS G13D None detected 10.4 
AML02 68/M Residual AML after induction therapy with monocytic differentiation; history of MPD, DLBCL PB JAK2; SRSF2 P95H; TET2 R550X; TP53 R175H Complex cytogenetics & t(4:11) 6.1 
AML03 High risk MDS/AML PB N/A del(13)(q12q22) and der(18)t(13;18)(q22;q23) 11.8 
AML04 25/M AML M2 BM FLT3-ITD Trisomy 8 4.4 
AML05 62/F AML/MPN PB JAK2 V617F; TP53 R248W; IDH2 R140Q None detected 5.9 
AML06 49/F Relapsed AML PB FLT3-ITD 46,XX 29 
AML07 73/M AML PB N/A 46,XY,t(1;4)(p21;q21)[3]/ 46,XY[7] 4.1 
AML08 70/M AML (monocytic) PB ASXL1 L823* (nonsense); BCOR R1183*; RUNX1 frameshift; SRSF2 P95H; TET2 insertion & R1516* None detected 10.3 
AML09 54/F AML (monocytic) PB FLT3-TKD; DNMT3A R882H; IDH1 R132H; MLL-PTD None detected 22 
AML10 61/F AML M5 with hyperleucocytosis BM FLT3-ITD; DNMT3A R882H; NPM1 frameshift None detected 12 
AML11 48/F AML (monocytic) PB CEBPA frameshift; CSF3R R698H; NF1 SNP None detected 2.5 
AML12 37/F AML PB FLT3-ITD 47,XX,+8[15]/ 46,XX[5] 21–24% trisomy 8 (D8Z2,RUNX1T1)x3[42-48/200] 1.9 
AML13 67/M AML PB MLL-PTD Trisomy 8 13.2 
AML14 59/F AML PB FLT3-ITD; NPM1; WT1 None detected 3.1 
AML15 38/M AML PB NRAS 46,XY t(9;11)(p22;q23) 3.6 
AML16 54/M AML PB DNMT3A, NPM1 None detected 12.7 
AML17 38/M AML PB N/A N/A 8.3 
AML18 29/M AML BM None detected t(8;21)(q22;q22) 45,X,-Y,t(8;21)(q22;q22)[20] 19.4 
AML19 61/M MDS/MPN/AML PB JAK2 46,XY,der(8) ?t(8;21)(q22;q22), del(9)(q13q22), dup(12)(q14q24.1), -22,+1-2mar[8]/46,xy(3) N/A 

Age, sex, diagnosis, sample type, molecular abnormalities, chromosomal abnormalities (fluorescence in situ hybridization, karyotyping), and IL1RAP expression (fold change in MFI relative to isotype control antibody stain) are shown where data were available. * indicates stop codon.

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