Table 1.
Retrovirus integration sites identified by inverse PCR
Mouse no.Gene nameGenome positionIntegration siteGene description
Ly6e chr15(qD3) 20 kb up Lymphocyte antigen 6 complex, locus E 
Fgd2 chr17(qA3,3) 15 kb down FYVE, RhoGEF, and PH domain containing 2 
H2-Eb2a chr17(qB1) Intron 1 Histocompatibility 2, class II antigen E beta2 
Fn1 chr1(qC3) 200 kb down Fibronectin 1 
Acvrl1 chr15(qF1) 10 kb down Activin A receptor, type II–like 1 
Rab37 chr11(qE2) Intron 1 RAB37, member RAS oncogene family 
Pitpnc1 chr11(qE1) Intron 1 Phosphatidylinositol transfer protein, cytoplasmic 1 
Zfp541 chr7(qA2) 15 kb up Zinc-finger protein 541 
Numb chr12(qD1) 15 kb up Numb homologue (Drosophila
Irf8 chr8(qE1) 50 kb down Interferon regulatory factor 8 
Rnf220a chr4(qD1) Intron 2 Ring-finger protein 220 
Fcnb chr2(qA3) 10 kb up Ficolin B 
Padi2 chr4(qD3) 1 kb up Peptidyl arginine deiminase, type II 
Kctd12 chr14(qE2,3) 100 kb down Potassium channel tetramerization domain containing 12 
Myb chr10(qA3) Intron 9 Myeloblastosis oncogene 
Hhexa chr19(qC2) 50 kb down Hematopoietically expressed homeobox 
Arpc3 chr5(qF) Intron 2 Actin-related protein 2/3 complex, subunit 3 
Setbp1 chr18(qE3) 200 kb up SET-binding protein 1 
M1ap chr(qC3) Exon 1 (5′ UTR) Meiosis 1–associated protein 
Ift81 chr5(qF) 10 kb up Intraflagellar transport 81 
Cmb1 chr15(qB2) 0.2 kb up Carboxymethylenebutenolidase-like (Pseudomonas
Gsn chr2(qB) 10 kb up Gelsolin 
Qars chr9(qF2) Intron 1 Glutaminyl-tRNA synthetase 
Rbbp6 chr7(qF2) 20 kb up Retinoblastoma-binding protein 6 
Prdm16 chr4(qE2) Intron 1 PR domain containing 16 
Mkln1 chr6(qA3,3) 200 kb up Muskelin 1, intracellular mediator containing kelch motifs 
Fhad1 chr4(qE1) Intron 13 Forkhead-associated phosphopeptide binding domain 1 
Rassf2 chr2(qF2) Intron 1 Ras association (RalGDS/AF-6) domain family member 2 
Neurl1b chr17(qA3,3) 20 kb up Neuralized E3 ubiquitin protein ligase 1B 
Rnf220a chr4(qD1) Intron 2 Ring finger protein 220 
EV1 chr12(qF1) Intron 1 Ena-vasodilator stimulated phosphoprotein 
Ubash3a chr17(qA3,3) Intron 6 Ubiquitin associated and SH3 domain containing, A 
Pcbp1 chr6(qD1) 20 kb down Poly(rC) binding protein 1 
Fggy chr4(qC5) 200 kb up FGGY carbohydrate kinase domain containing 
Adgre5 chr8(qC2) Intron 1 Adhesion G protein–coupled receptor E5 
Smim19 chr8(qA2) Exon 5 (3′ UTR) Small integral membrane protein 19 
Igch chr9(qC) Intron 13 IQ motif containing H 
Pim1 chr17(qA3,3) 1 kb up Proviral integration site 1 
Serpina3j chr12(qE) Intron 2 Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J 
Katnal1 chr5(qG3) 50 kb up Katanin p60 subunit A–like 1 
H2-Eb2a chr17(qB1) Intron 1 Histocompatibility 2, class II antigen E beta2 
Rere chr4(qE2) Intron 11 Arginine glutamic acid dipeptide (RE) repeats 
B3gnt2 chr11(qA3,2) Intron 1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 
Casp8 chr1(qC1,3) Intron 1 Caspase-8 
Hhexa chr19(qC2) 20 kb down Hematopoietically expressed homeobox 
Fam76a chr4(qD2,3) 20 kb up Family with sequence similarity 76, member A 
Rhoh chr5(qC3,1) 50 kb down ras homologue family member H 
Xxylt1 chr16(qB2) Intron 3 Xyloside xylosyltranserase 1 
Tmprss4 chr9(qA5,2) Intron 1 Transmembrane protease, serine 4 
Rras2 chr7(qF1) 50 kb up Related RAS viral (r-ras) oncogene 2 
Adrbk2 chr5(qF) Intron 1 Adrenergic receptor kinase, beta 2 
Stx6 chr1(G3) 5 kb up Syntaxin 6 
Ets2 chr16(qC4) 100 kb down E26 avian leukemia oncogene 2, 3′ domain 
Tmprss4 chr9(qA5,2) Intron 1 Transmembrane protease, serine 4 
Pla2g15 chr8(qD3) Intron 1 Phospholipase A2, group XV 
Zmiz1 chr14(qA3) 50 kb up Zinc finger, MIZ-type containing 1 
Brip1os chr11(qC) Intron 1 BRCA1-interacting protein C-terminal helicase 1, opposite strand 
Ephb2 chr4(qD3) Exon 1 (5′ UTR) Eph receptor B2 
Plin3 chr17 1 kb up Perilipin 3 
Mouse no.Gene nameGenome positionIntegration siteGene description
Ly6e chr15(qD3) 20 kb up Lymphocyte antigen 6 complex, locus E 
Fgd2 chr17(qA3,3) 15 kb down FYVE, RhoGEF, and PH domain containing 2 
H2-Eb2a chr17(qB1) Intron 1 Histocompatibility 2, class II antigen E beta2 
Fn1 chr1(qC3) 200 kb down Fibronectin 1 
Acvrl1 chr15(qF1) 10 kb down Activin A receptor, type II–like 1 
Rab37 chr11(qE2) Intron 1 RAB37, member RAS oncogene family 
Pitpnc1 chr11(qE1) Intron 1 Phosphatidylinositol transfer protein, cytoplasmic 1 
Zfp541 chr7(qA2) 15 kb up Zinc-finger protein 541 
Numb chr12(qD1) 15 kb up Numb homologue (Drosophila
Irf8 chr8(qE1) 50 kb down Interferon regulatory factor 8 
Rnf220a chr4(qD1) Intron 2 Ring-finger protein 220 
Fcnb chr2(qA3) 10 kb up Ficolin B 
Padi2 chr4(qD3) 1 kb up Peptidyl arginine deiminase, type II 
Kctd12 chr14(qE2,3) 100 kb down Potassium channel tetramerization domain containing 12 
Myb chr10(qA3) Intron 9 Myeloblastosis oncogene 
Hhexa chr19(qC2) 50 kb down Hematopoietically expressed homeobox 
Arpc3 chr5(qF) Intron 2 Actin-related protein 2/3 complex, subunit 3 
Setbp1 chr18(qE3) 200 kb up SET-binding protein 1 
M1ap chr(qC3) Exon 1 (5′ UTR) Meiosis 1–associated protein 
Ift81 chr5(qF) 10 kb up Intraflagellar transport 81 
Cmb1 chr15(qB2) 0.2 kb up Carboxymethylenebutenolidase-like (Pseudomonas
Gsn chr2(qB) 10 kb up Gelsolin 
Qars chr9(qF2) Intron 1 Glutaminyl-tRNA synthetase 
Rbbp6 chr7(qF2) 20 kb up Retinoblastoma-binding protein 6 
Prdm16 chr4(qE2) Intron 1 PR domain containing 16 
Mkln1 chr6(qA3,3) 200 kb up Muskelin 1, intracellular mediator containing kelch motifs 
Fhad1 chr4(qE1) Intron 13 Forkhead-associated phosphopeptide binding domain 1 
Rassf2 chr2(qF2) Intron 1 Ras association (RalGDS/AF-6) domain family member 2 
Neurl1b chr17(qA3,3) 20 kb up Neuralized E3 ubiquitin protein ligase 1B 
Rnf220a chr4(qD1) Intron 2 Ring finger protein 220 
EV1 chr12(qF1) Intron 1 Ena-vasodilator stimulated phosphoprotein 
Ubash3a chr17(qA3,3) Intron 6 Ubiquitin associated and SH3 domain containing, A 
Pcbp1 chr6(qD1) 20 kb down Poly(rC) binding protein 1 
Fggy chr4(qC5) 200 kb up FGGY carbohydrate kinase domain containing 
Adgre5 chr8(qC2) Intron 1 Adhesion G protein–coupled receptor E5 
Smim19 chr8(qA2) Exon 5 (3′ UTR) Small integral membrane protein 19 
Igch chr9(qC) Intron 13 IQ motif containing H 
Pim1 chr17(qA3,3) 1 kb up Proviral integration site 1 
Serpina3j chr12(qE) Intron 2 Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J 
Katnal1 chr5(qG3) 50 kb up Katanin p60 subunit A–like 1 
H2-Eb2a chr17(qB1) Intron 1 Histocompatibility 2, class II antigen E beta2 
Rere chr4(qE2) Intron 11 Arginine glutamic acid dipeptide (RE) repeats 
B3gnt2 chr11(qA3,2) Intron 1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 
Casp8 chr1(qC1,3) Intron 1 Caspase-8 
Hhexa chr19(qC2) 20 kb down Hematopoietically expressed homeobox 
Fam76a chr4(qD2,3) 20 kb up Family with sequence similarity 76, member A 
Rhoh chr5(qC3,1) 50 kb down ras homologue family member H 
Xxylt1 chr16(qB2) Intron 3 Xyloside xylosyltranserase 1 
Tmprss4 chr9(qA5,2) Intron 1 Transmembrane protease, serine 4 
Rras2 chr7(qF1) 50 kb up Related RAS viral (r-ras) oncogene 2 
Adrbk2 chr5(qF) Intron 1 Adrenergic receptor kinase, beta 2 
Stx6 chr1(G3) 5 kb up Syntaxin 6 
Ets2 chr16(qC4) 100 kb down E26 avian leukemia oncogene 2, 3′ domain 
Tmprss4 chr9(qA5,2) Intron 1 Transmembrane protease, serine 4 
Pla2g15 chr8(qD3) Intron 1 Phospholipase A2, group XV 
Zmiz1 chr14(qA3) 50 kb up Zinc finger, MIZ-type containing 1 
Brip1os chr11(qC) Intron 1 BRCA1-interacting protein C-terminal helicase 1, opposite strand 
Ephb2 chr4(qD3) Exon 1 (5′ UTR) Eph receptor B2 
Plin3 chr17 1 kb up Perilipin 3 
a

Retroviral common integration site.

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