Table 1. Kinetic constants of CXCL12,... | Rockefeller University Press

Table 1.

Kinetic constants of CXCL12, 3S, and BoxA binding to CXCR4

Ligand	Ka	Kd	K_D
	1/Ms	1/s	nM
CXCL12	1.5 × 10⁵	5.83 × 10⁻²	76.9
3S	6.81 × 10⁵	1.04 × 10⁻³	6.4
BoxA	5.75 × 10⁶	2.3 × 10⁻²	6.7

Ligand	Ka	Kd	K_D
	1/Ms	1/s	nM
CXCL12	1.5 × 10⁵	5.83 × 10⁻²	76.9
3S	6.81 × 10⁵	1.04 × 10⁻³	6.4
BoxA	5.75 × 10⁶	2.3 × 10⁻²	6.7

Curves derived from binding of CXCL12, 3S, and BoxA to immobilized lentiviral particles with membrane-bound CXCR4 were used to generate kinetic constants (Ka, Kd, K_D) by using a simple one-site interaction model with BIA Evaluation 4.1 software (GE Healthcare). Data are representative of three independent experiments.

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