Table 1.
Genetic mutations associated with primary atopic disorders.
Altered processGenes
Impaired TCR signaling and cytoskeletal remodeling ZAP70, CARD11, MALT1, WAS, WIPF1, ARPC1B, DOCK8, CARMIL2 
Altered cytokine signaling STAT3DN, STAT1GOF, STAT5BLOF, STAT5BGOF, JAK1GOF, IL4RAGOF, TGFBR1, TGFBR2, ERBB2IP 
T cell repertoire restriction  RAG1, RAG2, DCLRE1C, ADA, IL2RG, IL7RA, CHD7, LIG4, ZAP70, 22q11del 
Tolerance failure FOXP3, IL2RA, STAT5BLOF, TGFBR1, TGFBR2, WAS, CARD11, STAT1GOF 
Metabolic disturbance PGM3, CARD11, MALT1 
Skin barrier disruption FLG, CDSN, DSG1, DSP, SPINK5 
Mast cell deregulation KIT, PLCG2, ADGRE2, TPSAB1 
Altered processGenes
Impaired TCR signaling and cytoskeletal remodeling ZAP70, CARD11, MALT1, WAS, WIPF1, ARPC1B, DOCK8, CARMIL2 
Altered cytokine signaling STAT3DN, STAT1GOF, STAT5BLOF, STAT5BGOF, JAK1GOF, IL4RAGOF, TGFBR1, TGFBR2, ERBB2IP 
T cell repertoire restriction  RAG1, RAG2, DCLRE1C, ADA, IL2RG, IL7RA, CHD7, LIG4, ZAP70, 22q11del 
Tolerance failure FOXP3, IL2RA, STAT5BLOF, TGFBR1, TGFBR2, WAS, CARD11, STAT1GOF 
Metabolic disturbance PGM3, CARD11, MALT1 
Skin barrier disruption FLG, CDSN, DSG1, DSP, SPINK5 
Mast cell deregulation KIT, PLCG2, ADGRE2, TPSAB1 
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