Table 1. Comparison of phenotypes... | Rockefeller University Press

Table 1.

Comparison of phenotypes observed in proband and CRISPR/Cas9 Ikbkb mutant mouse

	Human IKBKB^V203I	Mouse Ikbkb^V203I
CD4⁺ T cells	Reduced	Reduced
CD8⁺ T cells	Reduced	Reduced
B cells	Reduced	Reduced
Memory B cells	Reduced	Reduced
T reg cells	Increased or normal	Increased
T cell activation	Increased (naive)	Increased
Phospho-IκBα	Constitutive activation	Constitutive activation

	Human IKBKB^V203I	Mouse Ikbkb^V203I
CD4⁺ T cells	Reduced	Reduced
CD8⁺ T cells	Reduced	Reduced
B cells	Reduced	Reduced
Memory B cells	Reduced	Reduced
T reg cells	Increased or normal	Increased
T cell activation	Increased (naive)	Increased
Phospho-IκBα	Constitutive activation	Constitutive activation