Table 1. HLA-A*02:01-binding affinity of... | Rockefeller University Press

Table 1.

HLA-A*02:01-binding affinity of H3.3K27M_26–35 mutant versus H3.3WT_26–35 nonmutant peptides

Peptide	Amino acid sequence	Predicted affinity (nM)/log score	Actual affinity (nM)
H3.3K27M	RMSAPSTGGV	285/0.477	151
H3.3WT	RKSAPSTGGV	22,651/0.073	>38,687

Peptide	Amino acid sequence	Predicted affinity (nM)/log score	Actual affinity (nM)
H3.3K27M	RMSAPSTGGV	285/0.477	151
H3.3WT	RKSAPSTGGV	22,651/0.073	>38,687

The predicted binding affinity was determined using the NetMHC3.4 server. Peptides were tested at six different concentrations covering a 100,000-fold dose range in three or more independent assays. The underlined letter suggests the position of mutation in the peptide epitope.

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