Table 1.
Immunoglobulin serum levels and anti-PnPS responses in CIN85 deficiency
Pat. no. 1Reference values
 mg/dl mg/dl   
Serum IgG4 <0.8 5.2–196   
Serum IgG3 60 24–116   
Serum IgG2 55 110–485   
Serum IgG1 595 370–910   
Serum IgA 79 40–238   
Serum IgG 918 672–1,536   
Serum IgM 16 48–228   
Pat. no. 1Reference values
 mg/dl mg/dl   
Serum IgG4 <0.8 5.2–196   
Serum IgG3 60 24–116   
Serum IgG2 55 110–485   
Serum IgG1 595 370–910   
Serum IgA 79 40–238   
Serum IgG 918 672–1,536   
Serum IgM 16 48–228   
Pat. no. 1 before vaccinationAfter vaccinationPat. no. 1 before vaccinationAfter vaccination
IgMIgMIgGIgG
 µg/ml µg/ml µg/ml µg/ml 
Anti-PnPS type 1 <0.03 0.13   
Anti-PnPS type 4 <0.02 0.22 0.22 0.74 
Anti-PnPS type 5 <0.03 1.70 0.31 0.48 
Anti-PnPS type 6B 0.08 0.46 0.25 0.42 
Anti-PnPS type 7F 0.06 1.10 0.1 0.24 
Anti-PnPS type 9V <0.03 0.12 0.03 0.66 
Anti-PnPS type 14 <0.08 0.90 <0.03 1.80 
Anti-PnPS type 18C <0.02 0.02 0.16 0.49 
Anti-PnPS type 19F 0.03 0.14 0.53 0.58 
Anti-PnPS type 23F 0.01 0.09 0.11 1.1 
Pat. no. 1 before vaccinationAfter vaccinationPat. no. 1 before vaccinationAfter vaccination
IgMIgMIgGIgG
 µg/ml µg/ml µg/ml µg/ml 
Anti-PnPS type 1 <0.03 0.13   
Anti-PnPS type 4 <0.02 0.22 0.22 0.74 
Anti-PnPS type 5 <0.03 1.70 0.31 0.48 
Anti-PnPS type 6B 0.08 0.46 0.25 0.42 
Anti-PnPS type 7F 0.06 1.10 0.1 0.24 
Anti-PnPS type 9V <0.03 0.12 0.03 0.66 
Anti-PnPS type 14 <0.08 0.90 <0.03 1.80 
Anti-PnPS type 18C <0.02 0.02 0.16 0.49 
Anti-PnPS type 19F 0.03 0.14 0.53 0.58 
Anti-PnPS type 23F 0.01 0.09 0.11 1.1 

Reference value for serotype specific anti-PnPS IgG ≥1.3 µg/ml. Reference values for IgM anti-PnPS type 1 (1.5 ± 0.4 µg/ml), type 4 (0.9 ± 0.4), and type 14 (0.7 ± 0.4) according to Carsetti et al. (2005). Variations from reference values are indicated in bold.

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