| Variable . | N . | Beta . | SE . | P . | Reference . |
|---|---|---|---|---|---|
| Fasting glucose (mmol/liter) | 46,186 | 0.004 | 0.005 | 0.42 | Dupuis et al., 2010 |
| Fasting insulin (pmol/liter) | 46,186 | −0.001 | 0.005 | 0.79 | Dupuis et al., 2010 |
| 2-h glucose (after OGTT) adjusted for BMI (mmol/liter) | 15,234 | 0.096 | 0.024 | 5.9E-05 | Saxena et al., 2010 |
| 30-min insulin secretion (after OGTT, ln) adjusted for BMI (pmol/liter) | 5,318 | −0.063 | 0.030 | 0.035 | Prokopenko et al., 2014 |
| Variable . | N . | Beta . | SE . | P . | Reference . |
|---|---|---|---|---|---|
| Fasting glucose (mmol/liter) | 46,186 | 0.004 | 0.005 | 0.42 | Dupuis et al., 2010 |
| Fasting insulin (pmol/liter) | 46,186 | −0.001 | 0.005 | 0.79 | Dupuis et al., 2010 |
| 2-h glucose (after OGTT) adjusted for BMI (mmol/liter) | 15,234 | 0.096 | 0.024 | 5.9E-05 | Saxena et al., 2010 |
| 30-min insulin secretion (after OGTT, ln) adjusted for BMI (pmol/liter) | 5,318 | −0.063 | 0.030 | 0.035 | Prokopenko et al., 2014 |
Data were downloaded from www.magicinvestigators.org. Specific regression coefficients (beta) and standard error (SE) represent changes in the variable per copy of the rs1052553 A major allele (H1 haplotype, frequency = 0.79). Trait values for fasting insulin and insulin secretion 30 min after an oral glucose tolerance test (OGTT) were naturally log transformed (ln). Results are adjusted for age, sex, study-specific covariates, and body mass index (BMI) where indicated. N, sample size.