Table 1. Regulation of known Wnt and... | Rockefeller University Press

Table 1.

Regulation of known Wnt and STAT3 target transcripts (RNA-seq)

Target	Log2 fold change	Adjusted P-value	Increased in Apc^Min/+ normal mucosa
Wnt signature in Apc^Min/+ tumor tissue
N-myc	1.2	8.51 × 10^–6	No
Axin2	1.1	7.13 × 10^–5	No
Mmp7	1.7	3.67 × 10^–5	No
Wnt5a	1.4	7.54 × 10^–13	No
Wnt7a	2.4	0.000181284	No
Efnb2	0.7	0.011594455	No
Efna2	0.9	0.012058086	No
Fgf18	1.8	0.00117603	No
Sox9	2.2	3.12 × 10^–11	No
Sox2	1.5	0.037838719	No
T	4.7	2.44 × 10^–16	No
Tbx1	2.8	4.02 × 10^–10	No
Tbx4	2.3	9.17 × 10^–6	No
Ccdn1	0.8	3.89 × 10^–6	No
Stat3 signature in Apc^Min/+ tumor tissue
Reg3b	1.5	0.002154754	No
Reg4	1.7	0.000230609	No
Areg	1.9	5.16 × 10^–7	No
Lrg1	3.5	1.96 × 10^–15	No
Trf	1.3	0.000473624	No
Pla2g2f	3.5	1.58 × 10^–14	No
Fut9	1.6	0.022056147	No
Saa1	1.6	0.011289854	No
Saa3	2.8	4.88 × 10^–12	No
Socs3	0.6	2.05 × 10^–6	Yes
Ncald	0.8	0.005328861	No
Duox2	2.1	4.35 × 10^–7	No
Duoxa2	2.5	1.68 × 10^–7	Yes

Target	Log2 fold change	Adjusted P-value	Increased in Apc^Min/+ normal mucosa
Wnt signature in Apc^Min/+ tumor tissue
N-myc	1.2	8.51 × 10^–6	No
Axin2	1.1	7.13 × 10^–5	No
Mmp7	1.7	3.67 × 10^–5	No
Wnt5a	1.4	7.54 × 10^–13	No
Wnt7a	2.4	0.000181284	No
Efnb2	0.7	0.011594455	No
Efna2	0.9	0.012058086	No
Fgf18	1.8	0.00117603	No
Sox9	2.2	3.12 × 10^–11	No
Sox2	1.5	0.037838719	No
T	4.7	2.44 × 10^–16	No
Tbx1	2.8	4.02 × 10^–10	No
Tbx4	2.3	9.17 × 10^–6	No
Ccdn1	0.8	3.89 × 10^–6	No
Stat3 signature in Apc^Min/+ tumor tissue
Reg3b	1.5	0.002154754	No
Reg4	1.7	0.000230609	No
Areg	1.9	5.16 × 10^–7	No
Lrg1	3.5	1.96 × 10^–15	No
Trf	1.3	0.000473624	No
Pla2g2f	3.5	1.58 × 10^–14	No
Fut9	1.6	0.022056147	No
Saa1	1.6	0.011289854	No
Saa3	2.8	4.88 × 10^–12	No
Socs3	0.6	2.05 × 10^–6	Yes
Ncald	0.8	0.005328861	No
Duox2	2.1	4.35 × 10^–7	No
Duoxa2	2.5	1.68 × 10^–7	Yes