| Identify chemistries and molecular targets of host immunity: use this information when developing drugs that target the pathogen . | Identify mechanisms of host–pathogen interactions: use this information when developing drugs that target the pathogen . | Identify mechanisms of host-pathogen interactions: use this information when developing drugs that target the host or to better understand host immunity . |
|---|---|---|
| Consider evolved principles of host immunity when setting criteria for chemical properties and when selecting targets of antimicrobial agents that will be used to treat contagious, life-threatening diseases (e.g., desirability of multiple targets, potential acceptability of low-level genotoxicity) | Identify and target pathways in the pathogen that allow it to evade host immunity or resist or repair the damage it inflicts | Bolster host immunity |
| Design antimicrobial agents that mimic or reproduce host immune chemistry (e.g., generation of reactive nitrogen species from nitroimidazoles) | Identify and target mechanisms of phenotypic tolerance displayed by bacteria in response to conditions in the host, including host immunity | Target pathways in the host that counteract effective host immunity or allow pathogens to evade it |
| Use elements of host immunity as antimicrobial agents (e.g., mAbs; members of the commensal microbiota) | Suppress immunopathology | |
| Use elements of immunity to help deliver antimicrobial agents (e.g., mAb–drug conjugates) | Use antimicrobial agents as tool compounds to identify new mechanisms of host immunity |
| Identify chemistries and molecular targets of host immunity: use this information when developing drugs that target the pathogen . | Identify mechanisms of host–pathogen interactions: use this information when developing drugs that target the pathogen . | Identify mechanisms of host-pathogen interactions: use this information when developing drugs that target the host or to better understand host immunity . |
|---|---|---|
| Consider evolved principles of host immunity when setting criteria for chemical properties and when selecting targets of antimicrobial agents that will be used to treat contagious, life-threatening diseases (e.g., desirability of multiple targets, potential acceptability of low-level genotoxicity) | Identify and target pathways in the pathogen that allow it to evade host immunity or resist or repair the damage it inflicts | Bolster host immunity |
| Design antimicrobial agents that mimic or reproduce host immune chemistry (e.g., generation of reactive nitrogen species from nitroimidazoles) | Identify and target mechanisms of phenotypic tolerance displayed by bacteria in response to conditions in the host, including host immunity | Target pathways in the host that counteract effective host immunity or allow pathogens to evade it |
| Use elements of host immunity as antimicrobial agents (e.g., mAbs; members of the commensal microbiota) | Suppress immunopathology | |
| Use elements of immunity to help deliver antimicrobial agents (e.g., mAb–drug conjugates) | Use antimicrobial agents as tool compounds to identify new mechanisms of host immunity |