Table 3.
In-depth immunophenotyping data of P1 at age 38
ParameterResultReference rangea
ANC 1,140 (↓) 1,500–7,700/ml 
CD14+ monocytes 330 165–780/ml 
ALC 670 1,000–4,800/µl 
CD3+ T cells 387 (↓); 62% 661–2,224/ml 
CD4+ T cells 281 (↓); 45% 356–1,573/ml 
CD8+ T cells 92 (↓); 15% 113–804/ml 
Circulating Tfh cellsb 12% 13.4–24.9% 
Partial effector Tfh cellsc 22.9% (↑) 9.26–11.1% 
Resting memory Tfh cellsd 30.6% (↓) 60.5–69% 
T reg cellse 7.74% 6.85–8.65% 
CD19+ B cells 159; 26% 143–396/ml 
Naive Bf 97.8% (↑) 14–58% 
Switched memory Bg 0.16% (↓) 23–60% 
CD3/16+ or 56+ 67 (↓); 11% 82–594/ml 
CD11c+ conventional DCh 3.29% 1.75–4.59% 
CD1c+i 3.38% 0.95–3.18% 
CD141+j 3.01% 1.33–3.09% 
ParameterResultReference rangea
ANC 1,140 (↓) 1,500–7,700/ml 
CD14+ monocytes 330 165–780/ml 
ALC 670 1,000–4,800/µl 
CD3+ T cells 387 (↓); 62% 661–2,224/ml 
CD4+ T cells 281 (↓); 45% 356–1,573/ml 
CD8+ T cells 92 (↓); 15% 113–804/ml 
Circulating Tfh cellsb 12% 13.4–24.9% 
Partial effector Tfh cellsc 22.9% (↑) 9.26–11.1% 
Resting memory Tfh cellsd 30.6% (↓) 60.5–69% 
T reg cellse 7.74% 6.85–8.65% 
CD19+ B cells 159; 26% 143–396/ml 
Naive Bf 97.8% (↑) 14–58% 
Switched memory Bg 0.16% (↓) 23–60% 
CD3/16+ or 56+ 67 (↓); 11% 82–594/ml 
CD11c+ conventional DCh 3.29% 1.75–4.59% 
CD1c+i 3.38% 0.95–3.18% 
CD141+j 3.01% 1.33–3.09% 

Because the measurements were performed in various clinical laboratories, ↓ indicates that at least one of the measurements during this time was lower than the reference range of the corresponding laboratory. ↑ indicates that at least one measurement was higher than the controls. ANC, absolute neutrophil count; ALC, absolute lymphocyte count.

a

Reference ranges from HCs.

b

CD45RA CD4+ CXCR5+.

c

CD45RA CD4+ CXCR5+ PD-1hi CCR7lo.

d

CD45RA CD4+ CXCR5+ PD-1lo CCR7hi.

e

CD4+ Foxp3+.

f

CD45+ CD19+ CD27 IgD+.

g

CD45+ CD19+ CD27+ IgD.

h

Lin1 HLA-DR+ CD11c+.

i

Lin1 HLA-DR+ CD11c+ CD1c+.

j

Lin1 HLA-DR+ CD11c+ CD141+.

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