Table 1.
Approximate LD50 values of influenza A viruses of avian or human origin in C57BL/6 mice carrying functional endogenous Mx1 genes (Mx1), lacking functional endogenous Mx1 (non-tg) or carrying the human MxA transgene (hMx-tg)
Influenza strainLD50 [pfu]
hMx-tgnon-tgMx1
Avian    
 KAN-1 (H5N1) >106 5 × 10° >106 
 R65 (H5N1) 8 × 104 5 × 10° 3 × 105 
 SH/1 (H7N9) 3 × 104 1 × 103 >105 
 SC35M (H7N7) 2 × 104 8 × 102 1 × 105 
Human    
 PR8 (H1N1) 2 × 103 1 × 103 >106 
 WSN (H1N1) 2 × 103 5 × 102 >4 × 105 
 HK68 (H3N2) 5 × 101 1 × 101 4 × 104 
Influenza strainLD50 [pfu]
hMx-tgnon-tgMx1
Avian    
 KAN-1 (H5N1) >106 5 × 10° >106 
 R65 (H5N1) 8 × 104 5 × 10° 3 × 105 
 SH/1 (H7N9) 3 × 104 1 × 103 >105 
 SC35M (H7N7) 2 × 104 8 × 102 1 × 105 
Human    
 PR8 (H1N1) 2 × 103 1 × 103 >106 
 WSN (H1N1) 2 × 103 5 × 102 >4 × 105 
 HK68 (H3N2) 5 × 101 1 × 101 4 × 104 
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