Table 1. DR-associated endothelial... | Rockefeller University Press

Table 1.

DR-associated endothelial ligands identified by comparative ligandomics

CCDS ID	Protein	Binding activity		Activity Ratio
CCDS ID	Protein	DR	Control	Activity Ratio
DR-high ligands with increased binding to diabetic ECs
CCDS23347.1	Scg3^{^a}	1,731	0	1,732
CCDS18810	C1qb^{^a}	837	0	838
CCDS15031	Fn1^{^a}	419	0	420
CCDS35631	Col4a3^{^a}	409	2	137
CCDS28285	APP^{^a}	206	1	104
CCDS22638	Cdh1^{^a}	132	0	133
DR-low ligands with decreased binding to diabetic ECs
CCDS40011	HRP-3^{^a}	48	11,140	0.0044
CCDS17457	HDGF^{^a}	0	83	0.0119
Internal positive and negative controls
VEGF-Phage		408	2,420	0.1689
GFP-Phage		10	10	1
Total identified sequences		489,126	473,965
Total identified ligands		1,548	844
Diabetes-related ligands^{^a}		353↑	105↓

CCDS ID	Protein	Binding activity		Activity Ratio
CCDS ID	Protein	DR	Control	Activity Ratio
DR-high ligands with increased binding to diabetic ECs
CCDS23347.1	Scg3^{^a}	1,731	0	1,732
CCDS18810	C1qb^{^a}	837	0	838
CCDS15031	Fn1^{^a}	419	0	420
CCDS35631	Col4a3^{^a}	409	2	137
CCDS28285	APP^{^a}	206	1	104
CCDS22638	Cdh1^{^a}	132	0	133
DR-low ligands with decreased binding to diabetic ECs
CCDS40011	HRP-3^{^a}	48	11,140	0.0044
CCDS17457	HDGF^{^a}	0	83	0.0119
Internal positive and negative controls
VEGF-Phage		408	2,420	0.1689
GFP-Phage		10	10	1
Total identified sequences		489,126	473,965
Total identified ligands		1,548	844
Diabetes-related ligands^{^a}		353↑	105↓

P < 0.001; DR versus control; χ² test. Activity ratio = (DR + 1)/(Control + 1).