| Subject . | Child’s age . | A*74 Gag 6SK1015 . | Frequency . | B*81 Pol 158SL10167 . | Frequency . | A*74 Pol 423SR10432 . | Frequency . | B*81 Nef 71RM979 . | Frequency . |
|---|---|---|---|---|---|---|---|---|---|
| SILRGGKLDK . | SPIETVPVKL . | SQIYPGIKVR . | RPQVPLRPM . | ||||||
| yr | |||||||||
| 133-M | 1.1 | ·····E···· | 100% | nd | nd | nd | |||
| 7 | ·V···E···· | 100% | ·········· | 100% | ·······R·· | 81% | ········· | 100% | |
| ······VR·· | 13% | ||||||||
| ·····R·R·· | 6% | ||||||||
| 133-C | 0.3 | ·····EN··· | 100% | ·········· | 65% | ·····R·R·· | 100% | ·····V··· | 60% |
| ···D······ | 32% | ········· | 32% | ||||||
| ····P····· | 2% | ···A····· | 6% | ||||||
| ···K······ | 1% | K········ | 2% | ||||||
| 2.7 | ·····EN··· | 75% | ·S········ | 92% | ·······RIK | 55% | ·····I··· | 54% | |
| ·V···EN··· | 24% | ···K······ | 5% | ·······R·K | 42% | ·····V··· | 36% | ||
| ·········· | 3% | ·····R·R·· | 3% | K····V··· | 8% | ||||
| ········· | 2% | ||||||||
| 4.9 | ·V···EN··· | 99% | ·S········ | 100% | ·······RIK | 98.7% | ·····T··· | 89% | |
| ·······R·K | 1.3% | ·····V··· | 11% | ||||||
| 7.7 | ·····EN··· | 100% | ·S········ | 76% | ·····R·R·K | 81% | ·····V··· | 99% | |
| ·T········ | 24% | ·······RIK | 17% | ||||||
| ·······R·K | 2% | ||||||||
| HLA association | HLA-A*74 | HLA-B*81 | HLA-A*74 | HLA-B*81 | |||||
| HLA-B*81 | |||||||||
| Escape variant | K12N | P189S | R432K | L76X | |||||
| E191X | |||||||||
| q value | 6 × 10−17 | 3 × 10−39 | 7 × 10−3 | 2 × 10−38 | |||||
| 3 × 10−4 |
| Subject . | Child’s age . | A*74 Gag 6SK1015 . | Frequency . | B*81 Pol 158SL10167 . | Frequency . | A*74 Pol 423SR10432 . | Frequency . | B*81 Nef 71RM979 . | Frequency . |
|---|---|---|---|---|---|---|---|---|---|
| SILRGGKLDK . | SPIETVPVKL . | SQIYPGIKVR . | RPQVPLRPM . | ||||||
| yr | |||||||||
| 133-M | 1.1 | ·····E···· | 100% | nd | nd | nd | |||
| 7 | ·V···E···· | 100% | ·········· | 100% | ·······R·· | 81% | ········· | 100% | |
| ······VR·· | 13% | ||||||||
| ·····R·R·· | 6% | ||||||||
| 133-C | 0.3 | ·····EN··· | 100% | ·········· | 65% | ·····R·R·· | 100% | ·····V··· | 60% |
| ···D······ | 32% | ········· | 32% | ||||||
| ····P····· | 2% | ···A····· | 6% | ||||||
| ···K······ | 1% | K········ | 2% | ||||||
| 2.7 | ·····EN··· | 75% | ·S········ | 92% | ·······RIK | 55% | ·····I··· | 54% | |
| ·V···EN··· | 24% | ···K······ | 5% | ·······R·K | 42% | ·····V··· | 36% | ||
| ·········· | 3% | ·····R·R·· | 3% | K····V··· | 8% | ||||
| ········· | 2% | ||||||||
| 4.9 | ·V···EN··· | 99% | ·S········ | 100% | ·······RIK | 98.7% | ·····T··· | 89% | |
| ·······R·K | 1.3% | ·····V··· | 11% | ||||||
| 7.7 | ·····EN··· | 100% | ·S········ | 76% | ·····R·R·K | 81% | ·····V··· | 99% | |
| ·T········ | 24% | ·······RIK | 17% | ||||||
| ·······R·K | 2% | ||||||||
| HLA association | HLA-A*74 | HLA-B*81 | HLA-A*74 | HLA-B*81 | |||||
| HLA-B*81 | |||||||||
| Escape variant | K12N | P189S | R432K | L76X | |||||
| E191X | |||||||||
| q value | 6 × 10−17 | 3 × 10−39 | 7 × 10−3 | 2 × 10−38 | |||||
| 3 × 10−4 |
Mother 133-M: A*74:01−, B*81:01−. VC child 133-C: A*74:01+, B*81:01+. Footprints associated with the HLA class I allele are indicated below the table; known escape variants and q values indicating significance of an HLA-polymorphism association are shown (Carlson et al., 2014). 133-M indicates mother of the child 133-C. Frequency represents percentage at which a particular haplotype is present at the indicated time point.