Table 2. Immune phenotype of patient 1,... | Rockefeller University Press

Table 2.

Immune phenotype of patient 1, 2, and 3

	Patient 1 (6 yr)				Patient 2 (8 yr)				Patient 3 (2 yr)
	Relative counts	Reference values	Absolute	Reference values	Relative counts	Reference values	Absolute	Reference values	Relative counts	Reference values	Absolute	Reference values
Lymphocytes^{^a}			1,855	1,800–5,000			900	1,800–5,000			4,950	2,800–6,400
B cells^{^a}	2.0	8.5–20.2	37	296–784	3.8	8.5–20.2	34	296–784	29.9	17.3–30.0	1,480	686–1,732
CD4^{^a}	4.0	26.5–41.4	74	641–1,453	24.5	26.5–41.4	220	641–1,453	6.4	28.1–43.2	317	925–2,477
CD8^{^b}	45.0	13–47	834	200–1,700	38.3	13–47	345	200–1,700	4.5	9–49	223	200–1,800
NK cells^{^b}	6.0	2–31	114	70–590	1.7	2–31	16	70–590	0.9	2–25	45	61–510
B cell subpopulations^{^a}	ND		ND						ND		ND
Transitional					21.1	3.4–9.0	5	13–63
Naive					68.7	47.8–69.8	23	154–413
IgM memory					3.5	6.3–22	2	24–135
IgM only					0.7	2–11.8	1	7–65
IgA cs memory					0	1.1–6.1	0	5–35
IgG cs memory					0	2.7–14	0	13–74
CD21^low					6.3
CD4 subpopulations^{^a}	ND		ND						ND		ND
RTE^{^c}					24.4	61–84.2	1
Naive					2.4	55.6–75.8	5	375–1,096
CD45R0					97.5	24–43
T reg cells					2.0	2.3–7.7	5	18–86
cTFH^{^d}					35.0	18.4–29.9	112	51–218
Th₂⁺Th₁₇-like cTFH^{^d}					29.4	39.9–66.1	33	26–85
CD8 subpopulations^{^b}	ND		ND						ND		ND
Naive					0.3	16–100	1	42–1,300
Central memory					2.4	1–6	8	6–43
Effector memory					65.9	5–100	227	45–410
Terminally differentiated					1.6	15–41	6	57–340
γδ T cells^{^e}	ND		ND		37.2	<10	282	12–175	72	<10	2,217	12–175
DN T cells^{^e}	51				38				72
NK T cells^{^e}	ND		ND		0.005	>0.01	ND		ND		ND

	Patient 1 (6 yr)				Patient 2 (8 yr)				Patient 3 (2 yr)
	Relative counts	Reference values	Absolute	Reference values	Relative counts	Reference values	Absolute	Reference values	Relative counts	Reference values	Absolute	Reference values
Lymphocytes^{^a}			1,855	1,800–5,000			900	1,800–5,000			4,950	2,800–6,400
B cells^{^a}	2.0	8.5–20.2	37	296–784	3.8	8.5–20.2	34	296–784	29.9	17.3–30.0	1,480	686–1,732
CD4^{^a}	4.0	26.5–41.4	74	641–1,453	24.5	26.5–41.4	220	641–1,453	6.4	28.1–43.2	317	925–2,477
CD8^{^b}	45.0	13–47	834	200–1,700	38.3	13–47	345	200–1,700	4.5	9–49	223	200–1,800
NK cells^{^b}	6.0	2–31	114	70–590	1.7	2–31	16	70–590	0.9	2–25	45	61–510
B cell subpopulations^{^a}	ND		ND						ND		ND
Transitional					21.1	3.4–9.0	5	13–63
Naive					68.7	47.8–69.8	23	154–413
IgM memory					3.5	6.3–22	2	24–135
IgM only					0.7	2–11.8	1	7–65
IgA cs memory					0	1.1–6.1	0	5–35
IgG cs memory					0	2.7–14	0	13–74
CD21^low					6.3
CD4 subpopulations^{^a}	ND		ND						ND		ND
RTE^{^c}					24.4	61–84.2	1
Naive					2.4	55.6–75.8	5	375–1,096
CD45R0					97.5	24–43
T reg cells					2.0	2.3–7.7	5	18–86
cTFH^{^d}					35.0	18.4–29.9	112	51–218
Th₂⁺Th₁₇-like cTFH^{^d}					29.4	39.9–66.1	33	26–85
CD8 subpopulations^{^b}	ND		ND						ND		ND
Naive					0.3	16–100	1	42–1,300
Central memory					2.4	1–6	8	6–43
Effector memory					65.9	5–100	227	45–410
Terminally differentiated					1.6	15–41	6	57–340
γδ T cells^{^e}	ND		ND		37.2	<10	282	12–175	72	<10	2,217	12–175
DN T cells^{^e}	51				38				72
NK T cells^{^e}	ND		ND		0.005	>0.01	ND		ND		ND

Relative counts are shown as a percentage of parental population. Absolute numbers refer to cells/microliter. CD4 T cell subpopulations: recent thymic emigrants (RTEs), CD31⁺ of CD45RA⁺ CD4 T cells; T reg cells, CD127⁻ CD25hi of CD45RA⁻ CD4 T cells; circulating T follicular helper–like cell (cTFH), CXCR5⁺ of CD45RA⁻ CD4 T cells; Th2/Th17-like cTFH, CXCR3⁻ of CXCR5⁺ CD45RA⁻ CD4 T cells. CD8 T cell populations: naive, CCR7⁺ CD45RA⁺ CD27⁺; terminally differentiated, CCR7⁻ CD45RA⁺ CD27⁻; central memory, CCR7⁺ CD45RA⁻ CD27⁺; effector memory, CCR7⁻ CD45RA⁻ CD27⁻. Double-negative (DN) T cells, CD4⁻/CD8⁻ of CD3 T cells. NK T cells, Vα24 Vβ11 CD3 T cells. cs, class switched.

van Gent et al., 2009.

Schatorjé et al., 2012.

Percentage of naive CD4 T cells.

Internal reference value.

Internal reference value of CD3 T cells.

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