Table 1. Characterization of cardiac... | Rockefeller University Press

Table 1.

Characterization of cardiac function in WT, in TCR-α^−/−, and in TCR-α^−/− mice after AT of naive, Th1, or IFN-γ^−/− Th cells 4 wk after sham or TAC

Parameters	WT sham	WT TAC	TCR-α^−/− Sham	TCR-α^−/− TAC	TCR-α^−/− TAC AT Naive	TCR-α^−/− TAC AT Th1	TCR-α^−/− TAC AT IFN-γ^−/−Th
Total mouse weight (g)/tibia length (mm)	1.45 ± 0.02	1.43 ± 0.02	1.45 ± 0.03	1.49 ± 0.04	1.46 ± 0.04	1.51 ± 0.01	1.48 ± 0.03
Lung weight (mg)/tibia length (cm)	91.77 ± 2	123 ± 9^{^a}	87.33 ± 3	88.11 ± 0	92.39 ± 2	92.32 ± 1	92.41 ± 2
Fractional shortening (%)	39.54 ± 4.036	23.80 ± 2.29^{^a}	30.92 ± 3.22	38.46 ± 4.10	31.25 ± 3.36	32.24 ± 3.87	30.88 ± 3.90
Anterior wall thickness (mm)	0.87 ± 0.03	1.08 ± 0.08^{^a}	0.75 ± 0.02	0.87 ± 0.03	0.83 ± 0.14	1.10 ± 0.11^{^a}^,^{^b}	0.90 ± 0.10
Posterior wall thickness (mm)	0.94 ± 0.05	1.3 ± 0.07^{^a}	0.73 ± 0.03	1.01 ± 0.12	0.83 ± 0.14	1.02 ± 0.07^{^c}	0.87 ± 0.08
End diastolic diameter (mm)	3.49 ± 0.08	3.99 ± 0.15^{^a}	4.01 ± 0.12	3.9 ± 0.22	4.16 ± 0.16	3.97 ± 0.18	4.08 ± 0.12
End systolic diameter (mm)	2.11 ± 0.16	3.04 ± 0.17^{^d}	2.77 ± 0.20	2.60 ± 0.28	2.86 ± 0.23	2.69 ± 0.24	2.82 ± 0.17
dp/dt min (mm Hg/s)	−8.28 ± 0.86	−5.61 ± 0.68^{^a}	−7.89 ± 0.39	−8.00 ± 1.06	−8.76 ± 1.06	−6.67± 0.70	−7.61 ± 1.12

Parameters	WT sham	WT TAC	TCR-α^−/− Sham	TCR-α^−/− TAC	TCR-α^−/− TAC AT Naive	TCR-α^−/− TAC AT Th1	TCR-α^−/− TAC AT IFN-γ^−/−Th
Total mouse weight (g)/tibia length (mm)	1.45 ± 0.02	1.43 ± 0.02	1.45 ± 0.03	1.49 ± 0.04	1.46 ± 0.04	1.51 ± 0.01	1.48 ± 0.03
Lung weight (mg)/tibia length (cm)	91.77 ± 2	123 ± 9^{^a}	87.33 ± 3	88.11 ± 0	92.39 ± 2	92.32 ± 1	92.41 ± 2
Fractional shortening (%)	39.54 ± 4.036	23.80 ± 2.29^{^a}	30.92 ± 3.22	38.46 ± 4.10	31.25 ± 3.36	32.24 ± 3.87	30.88 ± 3.90
Anterior wall thickness (mm)	0.87 ± 0.03	1.08 ± 0.08^{^a}	0.75 ± 0.02	0.87 ± 0.03	0.83 ± 0.14	1.10 ± 0.11^{^a}^,^{^b}	0.90 ± 0.10
Posterior wall thickness (mm)	0.94 ± 0.05	1.3 ± 0.07^{^a}	0.73 ± 0.03	1.01 ± 0.12	0.83 ± 0.14	1.02 ± 0.07^{^c}	0.87 ± 0.08
End diastolic diameter (mm)	3.49 ± 0.08	3.99 ± 0.15^{^a}	4.01 ± 0.12	3.9 ± 0.22	4.16 ± 0.16	3.97 ± 0.18	4.08 ± 0.12
End systolic diameter (mm)	2.11 ± 0.16	3.04 ± 0.17^{^d}	2.77 ± 0.20	2.60 ± 0.28	2.86 ± 0.23	2.69 ± 0.24	2.82 ± 0.17
dp/dt min (mm Hg/s)	−8.28 ± 0.86	−5.61 ± 0.68^{^a}	−7.89 ± 0.39	−8.00 ± 1.06	−8.76 ± 1.06	−6.67± 0.70	−7.61 ± 1.12

Values are means ± SEM.

P < 0.05, 4 wk of TAC versus sham.

P < 0.05, 4 wk TAC AT TCR-α^−/− versus TAC TCR-α^−/−.

P < 0.01, 4 wk TAC AT TCR-α^−/− versus TAC TCR-α^−/−.

P < 0.01, 4 wk of TAC versus sham.