| CLL BCR set . | Identical VH/VK BCR . | TC+ . | TC+ CD40–/– . | ≤2 mo B1 B cell origin . | |
|---|---|---|---|---|---|
| IgH . | IgL . | ||||
| VH genea . | Vk geneb . | n = 155 . | n = 18 . | n = 20 . | |
| 1 | VH12-1 (V261) | Vk4-91 (kf4) | 40 (25.8 %) | 4 (22.2%) | 4 |
| 2 | J558-64 (V332) | Vk12-89 (fl12) | 19 (12.3 %) | 3 (16.6%) | 2 |
| 3 | Q52-1 (V222) | Vk9-96 (ce9) | 14 (9.0 %) | 1 (5.6%) | 2 |
| 4 | J558-67 (V328) | Vk1-117 (cr1) | 10 (6.5 %) | 1 (5.6%) | 3 |
| 5 | VH11-2 (V235) | Vk9-128 (br9) | 4 (2.6 %) | 1 (5.6%) | nd |
| CLL BCR set . | Identical VH/VK BCR . | TC+ . | TC+ CD40–/– . | ≤2 mo B1 B cell origin . | |
|---|---|---|---|---|---|
| IgH . | IgL . | ||||
| VH genea . | Vk geneb . | n = 155 . | n = 18 . | n = 20 . | |
| 1 | VH12-1 (V261) | Vk4-91 (kf4) | 40 (25.8 %) | 4 (22.2%) | 4 |
| 2 | J558-64 (V332) | Vk12-89 (fl12) | 19 (12.3 %) | 3 (16.6%) | 2 |
| 3 | Q52-1 (V222) | Vk9-96 (ce9) | 14 (9.0 %) | 1 (5.6%) | 2 |
| 4 | J558-67 (V328) | Vk1-117 (cr1) | 10 (6.5 %) | 1 (5.6%) | 3 |
| 5 | VH11-2 (V235) | Vk9-128 (br9) | 4 (2.6 %) | 1 (5.6%) | nd |
Presence of CLL stereotyped BCRs in TCL1+(TC+) CLL samples expressing identical VH and VL combination, including CD40 deficiency, and CLL developed by IgM+ B1 B cell transfer from TC+ neonatal/young mice (≤2 mo old). n, total sample number. nd, not detected.
VH gene (see Table S1 and Vbase2 for parentheses).
Vk gene (Thiebe et al., 1999).