Table 1. Stereotyped BCRs in TCL1 CLL in... | Rockefeller University Press

Table 1.

Stereotyped BCRs in TCL1⁺ CLL in mice

CLL BCR set	Identical V_H/V_K BCR		TC⁺	TC⁺ CD40^–/–	≤2 mo B1 B cell origin
	IgH	IgL	TC⁺	TC⁺ CD40^–/–	≤2 mo B1 B cell origin
	V_H gene^{^a}	V_k gene^{^b}	n = 155	n = 18	n = 20
1	V_H12-1 (V261)	V_k4-91 (kf4)	40 (25.8 %)	4 (22.2%)	4
2	J558-64 (V332)	V_k12-89 (fl12)	19 (12.3 %)	3 (16.6%)	2
3	Q52-1 (V222)	V_k9-96 (ce9)	14 (9.0 %)	1 (5.6%)	2
4	J558-67 (V328)	V_k1-117 (cr1)	10 (6.5 %)	1 (5.6%)	3
5	V_H11-2 (V235)	V_k9-128 (br9)	4 (2.6 %)	1 (5.6%)	nd

CLL BCR set	Identical V_H/V_K BCR		TC⁺	TC⁺ CD40^–/–	≤2 mo B1 B cell origin
	IgH	IgL	TC⁺	TC⁺ CD40^–/–	≤2 mo B1 B cell origin
	V_H gene^a	V_k gene^b	n = 155	n = 18	n = 20
1	V_H12-1 (V261)	V_k4-91 (kf4)	40 (25.8 %)	4 (22.2%)	4
2	J558-64 (V332)	V_k12-89 (fl12)	19 (12.3 %)	3 (16.6%)	2
3	Q52-1 (V222)	V_k9-96 (ce9)	14 (9.0 %)	1 (5.6%)	2
4	J558-67 (V328)	V_k1-117 (cr1)	10 (6.5 %)	1 (5.6%)	3
5	V_H11-2 (V235)	V_k9-128 (br9)	4 (2.6 %)	1 (5.6%)	nd

Presence of CLL stereotyped BCRs in TCL1⁺(TC⁺) CLL samples expressing identical V_H and V_L combination, including CD40 deficiency, and CLL developed by IgM⁺ B1 B cell transfer from TC⁺ neonatal/young mice (≤2 mo old). n, total sample number. nd, not detected.

V_H gene (see Table S1 and Vbase2 for parentheses).

V_k gene (Thiebe et al., 1999).

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