| Mice group | Sirt1flox/flox;Apoe−/− | SVKO;Apoe−/− | |||||
|---|---|---|---|---|---|---|---|
| AL-AngII | CR-AngII | AL-Con | CR-Con | AL-AngII | CR-AngII | ||
| TG (mmol/liter) | 0.45 ± 0.1 (6) | 0.07 ± 0.03a (6) | 0.42 ± 0.04 (8) | 0.15 ± 0.08b (9) | 0.43 ± 0.06 (8) | 0.18 ± 0.04c (9) | |
| TC (mmol/liter) | 10.02 ± 1.09 (6) | 10.98 ± 1.47 (6) | 11.2 ± 0.52 (8) | 12.58 ± 1.04 (9) | 11.77 ± 1.48 (8) | 11.57 ± 0.74 (9) | |
| HDL-C (mmol/liter) | 0.5 ± 0.09 (6) | 0.46 ± 0.05 (6) | 0.52 ± 0.05 (8) | 0.53 ± 0.04 (9) | 0.52 ± 0.07 (8) | 0.56 ± 0.05 (9) | |
| LDL-C (mmol/liter) | 2.701 ± 0.27 (6) | 2.42 ± 0.45 (6) | 2.34 ± 0.18 (8) | 2.93 ± 0.2 (9) | 2.51 ± 0.3 (8) | 2.81 ± 0.16 (9) | |
| SBP (mmHg) | 130.9 ± 6.1 (6) | 126.2 ± 7.1 (8) | 92.8 ± 3.4 (8) | 100.7 ± 2.3 (10) | 127.4 ± 7.2d (9) | 126 ± 6.1e (11) | |
| Mice group | SVKO; | ||||||
|---|---|---|---|---|---|---|---|
| AL-AngII | CR-AngII | AL-Con | CR-Con | AL-AngII | CR-AngII | ||
| TG (mmol/liter) | 0.45 ± 0.1 (6) | 0.07 ± 0.03 | 0.42 ± 0.04 (8) | 0.15 ± 0.08 | 0.43 ± 0.06 (8) | 0.18 ± 0.04 | |
| TC (mmol/liter) | 10.02 ± 1.09 (6) | 10.98 ± 1.47 (6) | 11.2 ± 0.52 (8) | 12.58 ± 1.04 (9) | 11.77 ± 1.48 (8) | 11.57 ± 0.74 (9) | |
| HDL-C (mmol/liter) | 0.5 ± 0.09 (6) | 0.46 ± 0.05 (6) | 0.52 ± 0.05 (8) | 0.53 ± 0.04 (9) | 0.52 ± 0.07 (8) | 0.56 ± 0.05 (9) | |
| LDL-C (mmol/liter) | 2.701 ± 0.27 (6) | 2.42 ± 0.45 (6) | 2.34 ± 0.18 (8) | 2.93 ± 0.2 (9) | 2.51 ± 0.3 (8) | 2.81 ± 0.16 (9) | |
| SBP (mmHg) | 130.9 ± 6.1 (6) | 126.2 ± 7.1 (8) | 92.8 ± 3.4 (8) | 100.7 ± 2.3 (10) | 127.4 ± 7.2 | 126 ± 6.1 | |
The data are shown as the means ± SEM. Sample sizes (n) are shown in parenthesis. P-values were obtained using one-way ANOVA plus a posthoc analysis using a Bonferroni test in triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) or a Kruskal-Wallis test plus a posthoc analysis using a Dunn’s multiple comparison test in SBP.
P < 0.05 versus AL-AngII group of Sirt1flox/flox;Apoe−/− mice.
P < 0.01 versus AL-Con group of SVKO;Apoe−/− mice.
P < 0.01 versus AL-AngII group of SVKO;Apoe−/− mice.
P < 0.01 versus the AL-Con group of SVKO;Apoe−/− mice.
P < 0.01 versus the CR-Con group of SVKO;Apoe−/− mice.