| Parameter | II-2 2 yr old (normal range, ages 2–5 yr) | II-3 2 mo old (normal range, age 1 wk–2 mo) |
|---|---|---|
| Lymphocyte subsets (cells × 10−6/l) | ||
| CD3 | 1,215 (1610–4,230) | 2,449 (2,070–6,540) |
| CD4 | 784 (900–2,860) | 2,041 (1,460–5,116) |
| CD8 | 294 (630–1,900) | 233 (650–2,490) |
| CD4/CD8 ratio | 2.7 (1–2.1) | 8.8 (1.3–3.5) |
| Naive CD4+CD45RA+ T cells | ND | 38% (64–95%) |
| Memory CD4+CD45RO+ T cells | ND | 27% (2–22%) |
| Naïve CD8+CD45RA+ T cells | ND | 50% (80–99%) |
| Memory CD8+CD45RO+ T cells | ND | 13% (1–9%) |
| CD19 | 216 (700–1,300) | 2215 (500–1,500) |
| NK | 490 (130–920) | 933 (170–1,100) |
| Newborn TRECsa (Normal >40 copies/µl of blood) | 99 | 75 |
| Serum immunoglobulin | ||
| IgA (mg/dl) | 37 (14–123) | 39 (3–47) |
| IgM (mg/dl) | 25 (48–168) | 9 (17–105) |
| IgG (mg/dl) | 276 (424–1051) | 334 (206–601) |
| IgE IU/ml | 99 (<64) | ND |
| Lymphocyte proliferation | ||
| PHA (as % CD45; Normal ≥ 49.9%) | 1% | 2.4% |
| Candida (Normal >3 SI) | 1 | ND |
| Tetanus (Normal >3 SI) | 1.1 | ND |
| Specific antibody titers | ||
| Pneumococcal IgG, Type 3 | 0.2 (>1.3 µg/ml) | ND |
| Pneumococcal IgG, Type 8 | 0.7 (>1.3 µg/ml) | ND |
| Pneumococcal IgG, Type 12 | 0.3 (>1.3 µg/ml) | ND |
| Pneumococcal IgG, Type 14 | 1.6 (>1.3 µg/ml) | ND |
| Antitetanus toxoid | 1.64 (>0.15 IU/ml) | ND |
| Parameter | II-2 2 yr old (normal range, ages 2–5 yr) | II-3 2 mo old (normal range, age 1 wk–2 mo) |
|---|---|---|
| CD3 | 1,215 (1610–4,230) | 2,449 (2,070–6,540) |
| CD4 | 784 (900–2,860) | 2,041 (1,460–5,116) |
| CD8 | 294 (630–1,900) | 233 (650–2,490) |
| CD4/CD8 ratio | 2.7 (1–2.1) | 8.8 (1.3–3.5) |
| Naive CD4+CD45RA+ T cells | ND | 38% (64–95%) |
| Memory CD4+CD45RO+ T cells | ND | 27% (2–22%) |
| Naïve CD8+CD45RA+ T cells | ND | 50% (80–99%) |
| Memory CD8+CD45RO+ T cells | ND | 13% (1–9%) |
| CD19 | 216 (700–1,300) | 2215 (500–1,500) |
| NK | 490 (130–920) | 933 (170–1,100) |
| Newborn TRECs | 99 | 75 |
| IgA (mg/dl) | 37 (14–123) | 39 (3–47) |
| IgM (mg/dl) | 25 (48–168) | 9 (17–105) |
| IgG (mg/dl) | 276 (424–1051) | 334 (206–601) |
| IgE IU/ml | 99 (<64) | ND |
| PHA (as % CD45; Normal ≥ 49.9%) | 1% | 2.4% |
| Candida (Normal >3 SI) | 1 | ND |
| Tetanus (Normal >3 SI) | 1.1 | ND |
| Pneumococcal IgG, Type 3 | 0.2 (>1.3 µg/ml) | ND |
| Pneumococcal IgG, Type 8 | 0.7 (>1.3 µg/ml) | ND |
| Pneumococcal IgG, Type 12 | 0.3 (>1.3 µg/ml) | ND |
| Pneumococcal IgG, Type 14 | 1.6 (>1.3 µg/ml) | ND |
| Antitetanus toxoid | 1.64 (>0.15 IU/ml) | ND |
ND, not done; PHA, phytohemagglutinin.
TREC: T cell receptor excision circle, measured in dried blood spots retrieved with parental consent from archived newborn specimens.
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