Table 2. Gene ontology and diabetes... | Rockefeller University Press

Table 2.

Gene ontology and diabetes association of differentially expressed genes in βTRAF2 and βTRAF3 islets (chow and DIO)

	chow	DIO
Gene ontology^a
Regulation of cell growth, proliferation, apoptosis	Adora1, Bcat1, Gfra3, Grem2, Rasgrp1, Rerg, Sftpd, Socs2	Cish, Fmo1, Igfbp5, Ngfr, Prok1, Tph1, Tnfrsf11b
Metabolic processes	Adora1, Bcat1, Grem2, Ogdhl, Slca13, Wipi1	Fmo1, Ivd, Pde7b, Tph1, Srbd1
Potassium channel component	Hcn1, Kcnk10, Lrrcc55	Hcn1, Kcnj5
GPCR or GTPase related	Adora1, Gbp4, Gbp10, Gpr126, Gpr182, Penk, Rasgrp1	Cish, Gbp8, Gpr110, Kcnj5, Rph3a
Vesicle-associated	Crispld2, Krtap13-1, Rasgrp1, Wipi1	Rph3a, Syt10, Tmem2
Diabetes association^b
associated with type 1 diabetic phenotype in mouse models	Adora1, Bcat1, Gbp4, Gbp10, Hcn1, Rasgrp1	Fmo1, Ngfr, Tnfrsf11b
associated with type 2 diabetic phenotype in mouse models	Adora1, Bcat1, Gfra3, Gpr126, Hcn1, Kcnk10, Penk, Rasgrp1, Rerg, Sftpd, Socs2, Tnfrsf9, Wipi1	B3galnt1, B3galt1, Cish, Cym, Fmo1, Igfbp5, Kcnj5, Ngfr, Tnfrsf11b
associated with T1D in humans	Gbp4, Rasgrp1	Igfbp5, Tnfrsf11b
associated with T2D in humans	Bcat1, Rasgrp1, Sftpd	Adarb2, Igfbp5, Ivd, Kcnj5, Pde7b, Rerg, Rph3a, Slca13, Tnfrsf11b

	chow	DIO
Gene ontology^a
Regulation of cell growth, proliferation, apoptosis	Adora1, Bcat1, Gfra3, Grem2, Rasgrp1, Rerg, Sftpd, Socs2	Cish, Fmo1, Igfbp5, Ngfr, Prok1, Tph1, Tnfrsf11b
Metabolic processes	Adora1, Bcat1, Grem2, Ogdhl, Slca13, Wipi1	Fmo1, Ivd, Pde7b, Tph1, Srbd1
Potassium channel component	Hcn1, Kcnk10, Lrrcc55	Hcn1, Kcnj5
GPCR or GTPase related	Adora1, Gbp4, Gbp10, Gpr126, Gpr182, Penk, Rasgrp1	Cish, Gbp8, Gpr110, Kcnj5, Rph3a
Vesicle-associated	Crispld2, Krtap13-1, Rasgrp1, Wipi1	Rph3a, Syt10, Tmem2
Diabetes association^b
associated with type 1 diabetic phenotype in mouse models	Adora1, Bcat1, Gbp4, Gbp10, Hcn1, Rasgrp1	Fmo1, Ngfr, Tnfrsf11b
associated with type 2 diabetic phenotype in mouse models	Adora1, Bcat1, Gfra3, Gpr126, Hcn1, Kcnk10, Penk, Rasgrp1, Rerg, Sftpd, Socs2, Tnfrsf9, Wipi1	B3galnt1, B3galt1, Cish, Cym, Fmo1, Igfbp5, Kcnj5, Ngfr, Tnfrsf11b
associated with T1D in humans	Gbp4, Rasgrp1	Igfbp5, Tnfrsf11b
associated with T2D in humans	Bcat1, Rasgrp1, Sftpd	Adarb2, Igfbp5, Ivd, Kcnj5, Pde7b, Rerg, Rph3a, Slca13, Tnfrsf11b

Genes grouped by associated biological function according to DAVID Bioinformatics Database.

Genes associated with T1D and/or T2D in humans; genes associated with a diabetic phenotype in mouse models.