Top 15 most highly differentially expressed genes in βTRAF2 and βTRAF3 islets (chow and DIO)
| Genea | Log FCb | Associated functionc | |||
| βTRAF2 chow | βTRAF3 chow | βTRAF2 DIO | βTRAF3 DIO | ||
| Tph1 (tryptophan hydroxylase 1) | - | - | 6.88 | 6.33 | aromatic amino acid family metabolic process, bone remodeling, neuron projection, serotonin synthesis |
| Lrrc55 (leucine rich repeat containing 55) | 3.78 | 2.90 | 5.00 | 5.04 | potassium ion transport, BK channel auxiliary subunit |
| Sftpd (surfactant associated protein D) | 3.12 | 2.28 | 4.07 | 3.15 | phospholipid homeostasis, regulation of phagocytosis, LPS binding |
| Gbp8 (guanylate-binding protein 8) | 3.16 | - | 3.59 | 3.36 | large IFN-γ–induced GTPase |
| Syt10 (synaptotagmin X) | 3.20 | - | 3.53 | 3.24 | regulation of Ca2+-dependent exocytosis, cytoplasmic vesicle |
| Crispld2 (cysteine-rich secretory protein LCCL domain containing 2) | 3.36 | 3.33 | - | 2.68 | extracellular matrix (ECM) component, heparin binding, LPS binding, vesicle transport |
| Hcn1 (hyper-polarization-activated, cyclic nucleotide-gated K+ 1) | 2.75 | 2.40 | 3.36 | 3.24 | potassium ion transport; voltage-gated potassium channel, sensitivity to cAMP |
| Fbxw24 (F-box and WD-40 domain protein 24) | 2.91 | 1.82 | 3.48 | 2.99 | protein coding gene, unknown function |
| Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b) | - | - | 3.20 | 3.19 | osteoprotegerin (OPG), ECM organisation, regulation of differentiation, negative regulation of bone resorption, decoy receptor for RANKL |
| Matn2 (matrilin 2) | - | - | 3.42 | 2.92 | ECM, formation of filamentous networks, neuron cell migration,Ca2+-binding, |
| Rerg (RAS-like, estrogen-regulated, growth-inhibitor) | 2.13 | 1.56 | 3.30 | 3.04 | RAS superfamily of GTPases, negative regulator of cell growth/proliferation |
| Rasgrp1(RAS guanyl releasing protein 1) | 3.16 | 3.07 | - | 2.93 | GEF activity: activation of Ras and Rho GTPases, Ca2+ binding |
| Fmo1(flavin containing monooxygenase 1) | - | - | 3.16 | 2.55 | drug metabolic process; oxidation-reduction process; NADPH oxidation; organic acid metabolic process |
| Grem2 (gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)) | 2.19 | 1.49 | 2.54 | 2.28 | regulator of osteoblast differentiation and osteogenesis; cytokine, heparin binding, negative regulation of BMP signaling pathway |
| Gbp4 (guanylate binding protein 4) | 2.29 | 2.44 | large IFN-γ–induced GTPase negative regulation of protein ubiquitination | ||
| Genea | Log FCb | Associated functionc | |||
| βTRAF2 chow | βTRAF3 chow | βTRAF2 DIO | βTRAF3 DIO | ||
| Tph1 (tryptophan hydroxylase 1) | - | - | 6.88 | 6.33 | aromatic amino acid family metabolic process, bone remodeling, neuron projection, serotonin synthesis |
| Lrrc55 (leucine rich repeat containing 55) | 3.78 | 2.90 | 5.00 | 5.04 | potassium ion transport, BK channel auxiliary subunit |
| Sftpd (surfactant associated protein D) | 3.12 | 2.28 | 4.07 | 3.15 | phospholipid homeostasis, regulation of phagocytosis, LPS binding |
| Gbp8 (guanylate-binding protein 8) | 3.16 | - | 3.59 | 3.36 | large IFN-γ–induced GTPase |
| Syt10 (synaptotagmin X) | 3.20 | - | 3.53 | 3.24 | regulation of Ca2+-dependent exocytosis, cytoplasmic vesicle |
| Crispld2 (cysteine-rich secretory protein LCCL domain containing 2) | 3.36 | 3.33 | - | 2.68 | extracellular matrix (ECM) component, heparin binding, LPS binding, vesicle transport |
| Hcn1 (hyper-polarization-activated, cyclic nucleotide-gated K+ 1) | 2.75 | 2.40 | 3.36 | 3.24 | potassium ion transport; voltage-gated potassium channel, sensitivity to cAMP |
| Fbxw24 (F-box and WD-40 domain protein 24) | 2.91 | 1.82 | 3.48 | 2.99 | protein coding gene, unknown function |
| Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b) | - | - | 3.20 | 3.19 | osteoprotegerin (OPG), ECM organisation, regulation of differentiation, negative regulation of bone resorption, decoy receptor for RANKL |
| Matn2 (matrilin 2) | - | - | 3.42 | 2.92 | ECM, formation of filamentous networks, neuron cell migration,Ca2+-binding, |
| Rerg (RAS-like, estrogen-regulated, growth-inhibitor) | 2.13 | 1.56 | 3.30 | 3.04 | RAS superfamily of GTPases, negative regulator of cell growth/proliferation |
| Rasgrp1(RAS guanyl releasing protein 1) | 3.16 | 3.07 | - | 2.93 | GEF activity: activation of Ras and Rho GTPases, Ca2+ binding |
| Fmo1(flavin containing monooxygenase 1) | - | - | 3.16 | 2.55 | drug metabolic process; oxidation-reduction process; NADPH oxidation; organic acid metabolic process |
| Grem2 (gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)) | 2.19 | 1.49 | 2.54 | 2.28 | regulator of osteoblast differentiation and osteogenesis; cytokine, heparin binding, negative regulation of BMP signaling pathway |
| Gbp4 (guanylate binding protein 4) | 2.29 | 2.44 | large IFN-γ–induced GTPase negative regulation of protein ubiquitination | ||
Gene symbol and gene name.
Log fold change of differential gene expression in chow and DIO βTRAF2 and βTRAF3 islets.
Associated gene function according to DAVID Bioinformatics Database and Mouse Genome Database (MGD) at http://www.informatics.jax.org (September 2014).