Canonical pathway enrichment of shared genes
| Gene set name | No. genes in gene set (K) | No. genes in overlap (k) | k/K | P-value |
| TCA cycle and respiratory electron transport | 141 | 28 | 0.1986 | 6.66 × 10− 33 |
| VIF mediated degradation of apobec3g | 52 | 16 | 0.3077 | 1.04 × 10−22 |
| Class I MHC mediated antigen processing presentation | 251 | 25 | 0.0996 | 9.39 × 10−22 |
| Antigen processing ubiquitination proteasome degradation | 212 | 23 | 0.1085 | 5.87 × 10−21 |
| Proteasome | 48 | 14 | 0.2917 | 1.18 × 10−19 |
| ER phagosome pathway | 61 | 14 | 0.2295 | 5.09 × 10−18 |
| Cell cycle mitotic | 325 | 24 | 0.0738 | 6.79 × 10−18 |
| Cell cycle | 421 | 26 | 0.0618 | 2.22 × 10−17 |
| Antigen processing cross presentation | 76 | 14 | 0.1842 | 1.42 × 10−16 |
| Cross presentation of soluble exogenous antigens endosomes | 48 | 12 | 0.25 | 4.02 × 10−16 |
| Metabolism of mRNA | 284 | 20 | 0.0704 | 1.00 × 10−14 |
| Regulation of_mRNA stability by proteins that bind au rich elements | 84 | 13 | 0.1548 | 1.90 × 10−14 |
| Gene set name | No. genes in gene set (K) | No. genes in overlap (k) | k/K | P-value |
| TCA cycle and respiratory electron transport | 141 | 28 | 0.1986 | 6.66 × 10− 33 |
| VIF mediated degradation of apobec3g | 52 | 16 | 0.3077 | 1.04 × 10−22 |
| Class I MHC mediated antigen processing presentation | 251 | 25 | 0.0996 | 9.39 × 10−22 |
| Antigen processing ubiquitination proteasome degradation | 212 | 23 | 0.1085 | 5.87 × 10−21 |
| Proteasome | 48 | 14 | 0.2917 | 1.18 × 10−19 |
| ER phagosome pathway | 61 | 14 | 0.2295 | 5.09 × 10−18 |
| Cell cycle mitotic | 325 | 24 | 0.0738 | 6.79 × 10−18 |
| Cell cycle | 421 | 26 | 0.0618 | 2.22 × 10−17 |
| Antigen processing cross presentation | 76 | 14 | 0.1842 | 1.42 × 10−16 |
| Cross presentation of soluble exogenous antigens endosomes | 48 | 12 | 0.25 | 4.02 × 10−16 |
| Metabolism of mRNA | 284 | 20 | 0.0704 | 1.00 × 10−14 |
| Regulation of_mRNA stability by proteins that bind au rich elements | 84 | 13 | 0.1548 | 1.90 × 10−14 |
Enrichment (evaluated by hypergeometric test) of annotated canonical pathways among the genes that are shared between mouse module (Mm)1 and Human module (Hu)2 and which are enriched in the mouse CD8α+CD103+ cross-presenting DCs and human LCs, respectively. The list of these annotated genes (311) is provided in Table S3 and the pathways are annotated by REACTOME.