Table 1. Clinical and cellular... | Rockefeller University Press

Table 1.

Clinical and cellular phenotypes of TYK2-deficient patients

Parameter	Patient								Mouse data
	P1	P2	P3	P4	P5	P6	P7	P8
Sex	Male	Male	Female	Male	Male	Female	Female	Male
Country	Japan	Turkey	Morocco	Morocco	Iran	Iran	Iran	Argentina
Atopy/Dermatitis	yes	no	no	no	no	no	no	no
High IgE levels	yes	no	no	no	no	no	no	no
S. aureus infections	yes	no	no	no	no	no	no	no
Viral infections	HSV, PI3, MC	VZV	no	yes?	no	yes	no	HSV
Intracellular bacterial infections	BCG-osis, Salmonella	BCG-osis, Brucella	M. tuberculosis	yes?	BCG-osis	BCG-itis	M. tuberculosis	no
Fungal infections	C. albicans	no	no	no	no	no	no	no
Homozygous mutation	C70HfsX21	L767X	T1106HfsX4	T1106HfsX4	E154X	E154X	S50HfsX1	R638X
BCG vaccination	yes	yes	yes	yes	yes	yes	yes	yes
Response to IL-12 and IL-23	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired
Response to IFN-α	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired
Response to IL-10	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired	normal
Response to IL-6	impaired	normal	normal	normal	normal	normal	normal	normal	normal

Parameter	Patient								Mouse data
	P1	P2	P3	P4	P5	P6	P7	P8
Sex	Male	Male	Female	Male	Male	Female	Female	Male
Country	Japan	Turkey	Morocco	Morocco	Iran	Iran	Iran	Argentina
Atopy/Dermatitis	yes	no	no	no	no	no	no	no
High IgE levels	yes	no	no	no	no	no	no	no
S. aureus infections	yes	no	no	no	no	no	no	no
Viral infections	HSV, PI3, MC	VZV	no	yes?	no	yes	no	HSV
Intracellular bacterial infections	BCG-osis, Salmonella	BCG-osis, Brucella	M. tuberculosis	yes?	BCG-osis	BCG-itis	M. tuberculosis	no
Fungal infections	C. albicans	no	no	no	no	no	no	no
Homozygous mutation	C70HfsX21	L767X	T1106HfsX4	T1106HfsX4	E154X	E154X	S50HfsX1	R638X
BCG vaccination	yes	yes	yes	yes	yes	yes	yes	yes
Response to IL-12 and IL-23	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired
Response to IFN-α	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired
Response to IL-10	impaired	impaired	impaired	impaired	impaired	impaired	impaired	impaired	normal
Response to IL-6	impaired	normal	normal	normal	normal	normal	normal	normal	normal