Table 2.
Transcription factors predicted to regulate shared target genes of Ox-PAPC and NOTCH1 knockdown in HAECs
FactorGenesQ-value
Sin3a 536 1.17 × 10−22 
Corest 375 3.78 × 10−12 
P300 414 4.38 × 10−10 
Hdac2 290 2.35 × 10−9 
Hdac1 240 7.39 × 10−4 
Ctbp2 85 2.49 × 10−2 
Irf1 193 6.96 × 10−13 
Irf3 69 1.26 × 10−3 
Irf4 121 4.43 × 10−6 
Cebpb 374 4.88 × 10−10 
Cebpd 227 1.22 × 10−9 
Nfkb 364 4.01 × 10−12 
Stat1 42 1.52 × 10−3 
Stat2 43 1.39 × 10−10 
Stat3 93 6.44 × 10−5 
Egr1 460 8.54 × 10−13 
Creb1 360 5.26 × 10−11 
Atf1 179 1.19 × 10−6 
Atf2 192 3.59 × 10−4 
Atf3 243 1.03 × 10−5 
Srebp1 89 2.45 × 10−4 
Tal1 110 7.00 × 10−4 
FactorGenesQ-value
Sin3a 536 1.17 × 10−22 
Corest 375 3.78 × 10−12 
P300 414 4.38 × 10−10 
Hdac2 290 2.35 × 10−9 
Hdac1 240 7.39 × 10−4 
Ctbp2 85 2.49 × 10−2 
Irf1 193 6.96 × 10−13 
Irf3 69 1.26 × 10−3 
Irf4 121 4.43 × 10−6 
Cebpb 374 4.88 × 10−10 
Cebpd 227 1.22 × 10−9 
Nfkb 364 4.01 × 10−12 
Stat1 42 1.52 × 10−3 
Stat2 43 1.39 × 10−10 
Stat3 93 6.44 × 10−5 
Egr1 460 8.54 × 10−13 
Creb1 360 5.26 × 10−11 
Atf1 179 1.19 × 10−6 
Atf2 192 3.59 × 10−4 
Atf3 243 1.03 × 10−5 
Srebp1 89 2.45 × 10−4 
Tal1 110 7.00 × 10−4 

A subset of transcription factors predicted to regulate genes changed by 25%, 1% FDR by 50 µg/ml Ox-PAPC (6 h), and NOTCH1 knockdown are shown. The Genes column shows the number of genes in our list that are regulated by the indicated transcription factor.

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