Table 1.

Morphometric analysis of injured WT, PI3Kγ KD, and PI3Kγ KO femoral arteries

Mice Intima Media Lumen IEL EEL 
 μm2 μm2 μm2 μm2 μm2 
WT 26,020 ± 3,313 11,880 ± 1,344 12,100 ± 1,118 38,120 ± 3,713 49,990 ± 4,781 
PI3Kγ KD 10,580 ± 2,988** P = 0.0011 14,340 ± 1,384 P = 0.1138 22,250 ± 4,217* P = 0.0378 32,830 ± 3,737 P = 0.5981 47,170 ± 4,781 P = 0.8768 
PI3Kγ KO 7,850 ± 1,605*** P < 0.0001 14,300 ± 1,024 P = 0.0578 24,570 ± 3,564* P = 0.0103 32,420 ± 3,144 P = 0.5050 46,720 ± 3,882 P = 0.9591 
Mice Intima Media Lumen IEL EEL 
 μm2 μm2 μm2 μm2 μm2 
WT 26,020 ± 3,313 11,880 ± 1,344 12,100 ± 1,118 38,120 ± 3,713 49,990 ± 4,781 
PI3Kγ KD 10,580 ± 2,988** P = 0.0011 14,340 ± 1,384 P = 0.1138 22,250 ± 4,217* P = 0.0378 32,830 ± 3,737 P = 0.5981 47,170 ± 4,781 P = 0.8768 
PI3Kγ KO 7,850 ± 1,605*** P < 0.0001 14,300 ± 1,024 P = 0.0578 24,570 ± 3,564* P = 0.0103 32,420 ± 3,144 P = 0.5050 46,720 ± 3,882 P = 0.9591 

Femoral arteries from WT (n = 13), PI3Kγ KD (n = 9), and PI3Kγ KO mice (n = 11) were mechanically injured and analyzed 28 d after injury. IEL and EEL, respectively, indicate areas defined by the internal elastic laminae and external elastic laminae. Data are expressed as mean ± SEM for each group and are representative of two independent experiments, n = 9–13 mice per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001 versus WT controls. Data were analyzed with a Mann-Whitney test.

or Create an Account

Close Modal
Close Modal