Patients with B cell precursor ALL and somatic mutations in IL7R
| ID | IL7R mutation DNA | IL-7R mutation protein | CRLF2 | JAK2 | Gender | Age at Dx | WBC/liter | Events |
| yr | ||||||||
| DS46 | c.819 Ins 12 | 243 InsPPCL | P2RY8-CRLF2 | mut | M | 4.9 | 30.5 × 109 | first CCR |
| DS92 | c.642 A>T | S185C | IGHα translocation | WT | M | 15.1 | 112.8 × 109 | first CCR |
| M90 | c.828 Ins7 Del T | 246 InsKCH | P2RY8-CRLF2 | WT | M | 1.7 | 123 × 109 | relapse |
| M112 | c.642 A>T | S185C | P2RY8-CRLF2 | mut | F | 14.3 | 9.7 × 109 | relapse |
| M117 | c.814 Ins13 Del A | 241 InsFSCGP | P2RY8-CRLF2 | mut | F | 10.3 | 7 × 109 | first CCR |
| M122 | c.642 A>T | S185C | P2RY8-CRLF2 | WT | M | 7.0 | 7.3 × 109 | relapse |
| M124 | c.820 Ins10 Del C | 244 InsCHL | High expression | WT | M | 4.9 | 8.9 × 109 | first CCR |
| M223 | c.642 A>T | S185C | P2RY8-CRLF2 | WT | M | 8.0 | 27 × 109 | first CCR |
| M61 | c.820 ins21 | 244 InsPPVCSVT | CRLF2 not expressed | WT | M | 10.7 | 152 × 109 | relapse |
| ID | IL7R mutation DNA | IL-7R mutation protein | CRLF2 | JAK2 | Gender | Age at Dx | WBC/liter | Events |
| yr | ||||||||
| DS46 | c.819 Ins 12 | 243 InsPPCL | P2RY8-CRLF2 | mut | M | 4.9 | 30.5 × 109 | first CCR |
| DS92 | c.642 A>T | S185C | IGHα translocation | WT | M | 15.1 | 112.8 × 109 | first CCR |
| M90 | c.828 Ins7 Del T | 246 InsKCH | P2RY8-CRLF2 | WT | M | 1.7 | 123 × 109 | relapse |
| M112 | c.642 A>T | S185C | P2RY8-CRLF2 | mut | F | 14.3 | 9.7 × 109 | relapse |
| M117 | c.814 Ins13 Del A | 241 InsFSCGP | P2RY8-CRLF2 | mut | F | 10.3 | 7 × 109 | first CCR |
| M122 | c.642 A>T | S185C | P2RY8-CRLF2 | WT | M | 7.0 | 7.3 × 109 | relapse |
| M124 | c.820 Ins10 Del C | 244 InsCHL | High expression | WT | M | 4.9 | 8.9 × 109 | first CCR |
| M223 | c.642 A>T | S185C | P2RY8-CRLF2 | WT | M | 8.0 | 27 × 109 | first CCR |
| M61 | c.820 ins21 | 244 InsPPVCSVT | CRLF2 not expressed | WT | M | 10.7 | 152 × 109 | relapse |
DS, Down syndrome; M, male; F, female; mut, mutated at JAK2 R683; CCR, continuous complete remission; Dx, Diagnosis; Del, Deletion; Ins, Insertion; WBC, white blood cells count.