Cell cycle lesions are associated with patient risk by FLIPI
FL classification
Diploid
Gain/Loss
Total (%)
A
FLIPI low
20
6
26 (45)
FLIPI intermediate
6
9
15 (26)
FLIPI high
4
13
17 (29)
B
Grade 1
8
9
17 (29)
Grade 2
10
8
18 (31)
Grade 3A/B
12
11
23 (39)
FL classification
Diploid
Gain/Loss
Total (%)
A
FLIPI low
20
6
26 (45)
FLIPI intermediate
6
9
15 (26)
FLIPI high
4
13
17 (29)
B
Grade 1
8
9
17 (29)
Grade 2
10
8
18 (31)
Grade 3A/B
12
11
23 (39)
(A) Cell cycle lesions are significantly associated with high-risk by FLIPI. P = 0.002. (B) Lesions affecting CDK4, RB1, and CDKN2a/b occur across all FL grades without predilection. P = 0.08.