Rapamycin-insensitive up-regulation of PTGS2 and PTGIS expression in TSC-deficient LAM patient–derived cells are not affected by rapamycin treatment compared to TSC2-addback cells
| Gene | Protein | Fold change TSC−/vehicle versus TSC2+/vehicle | Fold change TSC2− rapamycin versus TSC2−/vehicle | Fold change TSC2−/rapamycin versus TSC2+/vehicle |
| PTGS2 | COX-2 | 2.1 (P = 0.004) | 1.3 (P = 0.05) | 2.8 (P = 0.0006) |
| PTGIS | Prostacyclin synthase (PGIS) | 40.4 (P = 0.00001) | 1.5 (P = 0.0006) | 61.1 (P = 0.000003) |
| Gene | Protein | Fold change TSC−/vehicle versus TSC2+/vehicle | Fold change TSC2− rapamycin versus TSC2−/vehicle | Fold change TSC2−/rapamycin versus TSC2+/vehicle |
| COX-2 | 2.1 (P = 0.004) | 1.3 (P = 0.05) | 2.8 (P = 0.0006) | |
| Prostacyclin synthase (PGIS) | 40.4 (P = 0.00001) | 1.5 (P = 0.0006) | 61.1 (P = 0.000003) |