Assessment of parameters of inflammationa
| Salineb | LPSb | Eta + LPS | GTN + LPS | NP Saline | NP LPS | |
| No. of WBCc | 3.52 (1.4–4.6)h | 6.29 (3.4–8.5) | 4.03 (1.3–5.8)e | 3.06 (1.2–5.9)h | 3.55 (2.5–4.8)g | 2.23 (1.1–3)h |
| No. of monocytesc | 0.31 (0.1–0.6)e | 0.57 (0.2–1.0) | 0.31 (0.1–0.5)e | 0.25 (0.1–0.5)g | 0.42 (0.2–0.6) | 0.2 (0.1–0.3)e |
| No. of granulocytesc | 2.2 (1.0–2.9)h | 4.1 (2.2–5.7) | 2.76 (0.9–3.9)e | 2.06 (0.8–3.1)h | 1.55 (1.4–1.8)i | 1.2 (0.4–1.8)i |
| No. of lymphocytesc | 1.01 (0.3–1.6)f | 1.61 (0.7–2.6) | 0.95 (0.3–1.4)f | 0.75 (0.3–1.4)e | 1.58 (0.9–2.7) | 0.83 (0.4–0.9)f |
| No. of animals (CBC analysis) | 10 | 11 | 8 | 8 | 6 | 4 |
| No. animals (TNF analysis) | 7 | 7 | 5 | 6 | 4 | 4 |
| Plasma TNF (pg/ml)d | undetectable (0) | 1285 (0–33643)k | 2132 (0–8377.2)j | 111.1 (0–127.3) | undetectable (0) | 61.05 (0–240.8) |
| Salineb | LPSb | Eta + LPS | GTN + LPS | NP Saline | NP LPS | |
| No. of WBCc | 3.52 (1.4–4.6)h | 6.29 (3.4–8.5) | 4.03 (1.3–5.8)e | 3.06 (1.2–5.9)h | 3.55 (2.5–4.8)g | 2.23 (1.1–3)h |
| No. of monocytesc | 0.31 (0.1–0.6)e | 0.57 (0.2–1.0) | 0.31 (0.1–0.5)e | 0.25 (0.1–0.5)g | 0.42 (0.2–0.6) | 0.2 (0.1–0.3)e |
| No. of granulocytesc | 2.2 (1.0–2.9)h | 4.1 (2.2–5.7) | 2.76 (0.9–3.9)e | 2.06 (0.8–3.1)h | 1.55 (1.4–1.8)i | 1.2 (0.4–1.8)i |
| No. of lymphocytesc | 1.01 (0.3–1.6)f | 1.61 (0.7–2.6) | 0.95 (0.3–1.4)f | 0.75 (0.3–1.4)e | 1.58 (0.9–2.7) | 0.83 (0.4–0.9)f |
| No. of animals (CBC analysis) | 10 | 11 | 8 | 8 | 6 | 4 |
| No. animals (TNF analysis) | 7 | 7 | 5 | 6 | 4 | 4 |
| Plasma TNF (pg/ml)d | undetectable (0) | 1285 (0–33643)k | 2132 (0–8377.2)j | 111.1 (0–127.3) | undetectable (0) | 61.05 (0–240.8) |
WBC, white blood cells; NP, non-pregnant.
Some data are represented in Fig. 1, B–D.
CBCs were performed on GD 17.5, 24 h after the last LPS injection. Data are expressed as mean (range).
Plasma was collected 2 h after saline/LPS administration to NP animals or 2 h after saline/LPS administration to pregnant animals on GD 13.5. Data are represented as median (range).
P < 0.1 versus LPS.
P < 0.05 versus LPS.
P < 0.01 versus LPS.
P < 0.001 versus LPS.
P < 0.0001 versus LPS.
P < 0.05 versus saline.
P < 0.01 versus saline.