Table 1. Transcriptomes of intracardiac... | Rockefeller University Press

Table 1.

Transcriptomes of intracardiac Ly6C^hi and Ly6C^lo MO/MΦs

Gene	Ly6C^hi MO/MΦ	95% CI	Ly6C^lo MO/MΦ	95% CI	P-value	Ly6C^hi/Ly6C^lo Ratio
	GeoMean		GeoMean
*Ccr2*	2.97⁺⁰⁰	(2.49⁺⁰⁰, 3.45⁺⁰⁰)	2.10⁺⁰⁰	(1.94⁺⁰⁰, 2.26⁺⁰⁰)	0.0270	1.41
*Il1b*	7.54⁺⁰¹	(6.40⁺⁰¹, 8.68⁺⁰¹)	1.97⁺⁰¹	(1.48⁺⁰¹, 2.45⁺⁰¹)	0.0009	3.84
*Il6*	1.80⁺⁰⁰	(1.14⁺⁰⁰, 2.47⁺⁰⁰)	2.51⁻⁰¹	(1.58⁻⁰¹, 3.43⁻⁰¹)	0.0093	7.19
*Il12a*	7.55⁻⁰²	(4.03⁻⁰², 1.11⁻⁰¹)	1.65⁻⁰³	(0, 1.03⁻⁰²)	0.0170	45.78
*Tnf*	2.36⁺⁰⁰	(1.39⁺⁰⁰, 3.33⁺⁰⁰)	7.83⁻⁰¹	(3.67⁻⁰¹, 1.20⁺⁰⁰)	0.0392	3.02
*Lyz2*	1.42⁺⁰²	(9.97⁺⁰¹, 1.85⁺⁰²)	7.17⁺⁰¹	(5.03⁺⁰¹, 9.30⁺⁰¹)	0.0411	1.99
*Nos2*	7.13⁻⁰²	(3.44⁻⁰², 1.08⁻⁰¹)	1.57⁻⁰²	(1.05⁻⁰², 2.09⁻⁰²)	0.0341	4.54
*Thbs1*	2.68⁺⁰⁰	(1.39⁺⁰⁰, 3.98⁺⁰⁰)	3.83⁻⁰¹	(3.25⁻⁰¹, 4.42⁻⁰¹)	0.0199	7.00
*Arg2*	1.33⁺⁰⁰	(1.09⁺⁰⁰, 1.58⁺⁰⁰)	4.83⁻⁰¹	(1.93⁻⁰¹, 7.73⁻⁰¹)	0.0136	2.76
*Chi3l3*	6.80⁻⁰¹	(4.10⁻⁰¹, 9.50⁻⁰¹)	6.28⁻⁰²	(1.51⁻⁰², 1.11⁻⁰¹)	0.0105	10.83
*Cx3cr1*	1.00⁺⁰⁰	(3.84⁻⁰¹, 1.63⁺⁰⁰)	2.39⁺⁰⁰	(2.09⁺⁰⁰, 2.70⁺⁰⁰)	0.0212	0.419
*Igf1*	6.10⁻⁰⁵	(8.28⁻⁰⁶, 1.14⁻⁰⁴)	2.66⁻⁰²	(1.15⁻⁰², 4.16⁻⁰²)	0.0207	0.002
*Mmp9*	6.12⁻⁰³	(0, 1.49⁻⁰²)	3.01⁻⁰²	(2.34⁻⁰², 3.68⁻⁰²)	0.0194	0.203
*Mmp12*	1.57⁻⁰¹	(0, 3.59⁻⁰¹)	1.15⁺⁰⁰	(7.77⁻⁰¹, 1.51⁺⁰⁰)	0.0103	0.137

Gene	Ly6C^hi MO/MΦ	95% CI	Ly6C^lo MO/MΦ	95% CI	P-value	Ly6C^hi/Ly6C^lo Ratio
	GeoMean		GeoMean
*Ccr2*	2.97⁺⁰⁰	(2.49⁺⁰⁰, 3.45⁺⁰⁰)	2.10⁺⁰⁰	(1.94⁺⁰⁰, 2.26⁺⁰⁰)	0.0270	1.41
*Il1b*	7.54⁺⁰¹	(6.40⁺⁰¹, 8.68⁺⁰¹)	1.97⁺⁰¹	(1.48⁺⁰¹, 2.45⁺⁰¹)	0.0009	3.84
*Il6*	1.80⁺⁰⁰	(1.14⁺⁰⁰, 2.47⁺⁰⁰)	2.51⁻⁰¹	(1.58⁻⁰¹, 3.43⁻⁰¹)	0.0093	7.19
*Il12a*	7.55⁻⁰²	(4.03⁻⁰², 1.11⁻⁰¹)	1.65⁻⁰³	(0, 1.03⁻⁰²)	0.0170	45.78
*Tnf*	2.36⁺⁰⁰	(1.39⁺⁰⁰, 3.33⁺⁰⁰)	7.83⁻⁰¹	(3.67⁻⁰¹, 1.20⁺⁰⁰)	0.0392	3.02
*Lyz2*	1.42⁺⁰²	(9.97⁺⁰¹, 1.85⁺⁰²)	7.17⁺⁰¹	(5.03⁺⁰¹, 9.30⁺⁰¹)	0.0411	1.99
*Nos2*	7.13⁻⁰²	(3.44⁻⁰², 1.08⁻⁰¹)	1.57⁻⁰²	(1.05⁻⁰², 2.09⁻⁰²)	0.0341	4.54
*Thbs1*	2.68⁺⁰⁰	(1.39⁺⁰⁰, 3.98⁺⁰⁰)	3.83⁻⁰¹	(3.25⁻⁰¹, 4.42⁻⁰¹)	0.0199	7.00
*Arg2*	1.33⁺⁰⁰	(1.09⁺⁰⁰, 1.58⁺⁰⁰)	4.83⁻⁰¹	(1.93⁻⁰¹, 7.73⁻⁰¹)	0.0136	2.76
*Chi3l3*	6.80⁻⁰¹	(4.10⁻⁰¹, 9.50⁻⁰¹)	6.28⁻⁰²	(1.51⁻⁰², 1.11⁻⁰¹)	0.0105	10.83
*Cx3cr1*	1.00⁺⁰⁰	(3.84⁻⁰¹, 1.63⁺⁰⁰)	2.39⁺⁰⁰	(2.09⁺⁰⁰, 2.70⁺⁰⁰)	0.0212	0.419
*Igf1*	6.10⁻⁰⁵	(8.28⁻⁰⁶, 1.14⁻⁰⁴)	2.66⁻⁰²	(1.15⁻⁰², 4.16⁻⁰²)	0.0207	0.002
*Mmp9*	6.12⁻⁰³	(0, 1.49⁻⁰²)	3.01⁻⁰²	(2.34⁻⁰², 3.68⁻⁰²)	0.0194	0.203
*Mmp12*	1.57⁻⁰¹	(0, 3.59⁻⁰¹)	1.15⁺⁰⁰	(7.77⁻⁰¹, 1.51⁺⁰⁰)	0.0103	0.137

EAM and DCMi were induced in WT mice. Mice were sacrificed 21 d after immunization. Ly6G⁻CD11b⁺Ly6C^hi (Ly6C^hi) and Ly6G⁻CD11b⁺Ly6C^lo (Ly6C^lo) MO/MΦ populations were isolated from mouse hearts by FACS. mRNA levels were determined by real-time qPCR and normalized to housekeeping gene Hprt. Data are representative of 2 independent experiments. Geometric mean of 3 replicates and 95% confidence interval (95% CI) are shown. The ratios of the mRNA levels in Ly6C^hi population to Ly6C^lo population are calculated. Data are analyzed by unpaired two-tailed Student’s t test.

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