Table 1.

Global analysis of unique mutation frequencies of the JH4 intronic region

JH4 intronic region WT Fanca−/− P-value 
Number of mice 5 5  
Mutated sequences analyzed 150 161  
Unique mutations (total) 787 665  
Overall mutation frequency 10.5 x 10−2 8.8 x 10−2 0.0008 
A/T mutations 11.2 x 10−2 8.7 x 10−2 0.0001 
Transversions 9.1 x 10−2 8.2 x 10−2 0.2637 
Transitions 15.5 x 10−2 9.7 x 10−2 <10−5 
Motif    
 WA 33.7 x 10−2 19.7 x 10−2 <10−4 
 TW 14.7 x 10−2 9.5 x 10−2 0.1637 
 G/C mutations 9.4 x 10−2 9.0 x 10−2 0.6013 
 Transversions 6.9 x 10−2 6.4 x 10−2 0.5355 
 Transitions 14.5 x 10−2 14.3 x 10−2 0.9504 
Motif    
 WRC 53.3 x 10−2 44.0 x 10−2 0.327 
 GYW 36.8 x 10−2 36.8 x 10−2 1.0 

All mutation frequencies were calculated according to the SHMTool algorithm. Bold denotes a significant decrease in the mutation frequency compared with WT. Underlining indicates the mutated residues in the motifs.

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