The frequency of human H chains with Arg in CDR3 in antibodies expressing Vκ editor, Vκ non-editor, and Vλ 5-6 human L chains from sorted peripheral blood
B cell population that expresses:
Number of H chain sequences analyzed
Number of H chains with Arg in CDR3
Vκ editors
72
43 (60%)*
Vκ non-editors
194
77 (40%)
Vλ 5-6
142
47 (33%)
B cell population that expresses:
Number of H chain sequences analyzed
Number of H chains with Arg in CDR3
Vκ editors
72
43 (60%)*
Vκ non-editors
194
77 (40%)
Vλ 5-6
142
47 (33%)
The number and percentage of H chains with Arg in CDR3 region in antibodies expressing Vκ editor, Vκ non-editor, and Vλ 5-6 L chains are shown. The CDR regions were identified according to the Kabat numbering scheme. *, P < 0.005, χ2 test.