Table 4.

The frequency of human H chains with Arg in CDR3 in antibodies expressing Vκ editor, Vκ non-editor, and Vλ 5-6 human L chains from sorted peripheral blood

B cell population that expresses: Number of H chain sequences analyzed Number of H chains with Arg in CDR3 
Vκ editors 72 43 (60%)* 
Vκ non-editors 194 77 (40%) 
Vλ 5-6 142 47 (33%) 
B cell population that expresses: Number of H chain sequences analyzed Number of H chains with Arg in CDR3 
Vκ editors 72 43 (60%)* 
Vκ non-editors 194 77 (40%) 
Vλ 5-6 142 47 (33%) 

The number and percentage of H chains with Arg in CDR3 region in antibodies expressing Vκ editor, Vκ non-editor, and Vλ 5-6 L chains are shown. The CDR regions were identified according to the Kabat numbering scheme. *, P < 0.005, χ2 test.

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