Protein sequences of mouse editor, human potential editor and human non-editor light chains analyzed in this study
| Name | FW1 | CDR1 | FW2 | CDR2 | FW3 | CDR3 |
| Mouse editor light chains | ||||||
| VκBt20 | STTVTQSPASLSMAIGEKVTIRC | ITSTDIDD------DMN | WYQQKPGEPPKLLIS | EGNTLRP----- | GVPSRFSSSGYGTDFVFTIENMLSEDVADYYCL | QSDNLP---- |
| VκBw20 | ETTVTQSPASLSVATGEKVTIRC | ITSTDIDD------DMN | WYQQKPGEPPKLLIS | EGNTLRP----- | GVPSRFSSSGYGTDFVFTIENTLSEDVADYYCL | QSDNMP---- |
| Vκ21-4 | DIVLTQSPASLAVSLGQRATISC | KASQS-VDYD-GDSYMN | WYQQKPGQPPKLLIY | AASNLES----- | GIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQ | QSNEDP---- |
| Vκ12-46 | DIQMTQSPASLSVSVGETVTITC | RASENIYS------NLA | WYQQKQGKSPQLLVY | AATNLAD----- | GVPSRFSGSGSGTQYSLKINSLQSEDFGSYYCQ | HFWGTP---- |
| VκGj38c | DIQMTQSPSSLSASLGGKVTITC | KASQDINK------YIA | WYQHKPGKGPRLLIH | YTSTLQP----- | GIPSRFSGSGSGRDYSFSISNLEPEDIATYYCL | QYDNLL---- |
| VλX | QLVLTQSS-SASFSLGASAKLTC | TLSSQHST-----YTIE | WYQQQPLKPPKYVME | LKKDGSH-STGD | GIPDRFSGSSSGADRYLSISNIQPEDEAIYIC | GVGDTIKEQFV |
| Human potential editor light chains | ||||||
| VκO8/O18 | DIQMTQSPSSLSASVGDRVTITC | QASQDISN------YLN | WYQQKPGKAPKLLIY | DASNLET----- | GVPSRFSGSGSGTDFTFTISSLQPEDIATYYC | QQYDNLP---- |
| VκL11 | AIQMTQSPSSLSASVGDRVTITC | RASQGIRN------DLG | WYQQKPGKAPKLLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | LQDYNYP---- |
| VκO2/O12 | DIQMTQSPSSLSASVGDRVTITC | RASQSISS------YLN | WYQQKPGKAPKLLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQSYSTP---- |
| Vλ5-1 | LPVLTQPPSASALLGASIKLTCT | LSSEHST------YTIE | WYQQRPGRSPQYIMK | VKSDGSH-SKGD | GIPDRFMGSSSGADRYLTFSNLQSDDEAEYHC | GESHTIDGQVG |
| Vλ5-2 | QPVLTQPPSASASLGASVTLTCT | LSSGYSN------YKVD | WYQQRPGKGPRFVMR | VGTGGIVGSKGD | GIPDRFSVLGSGLNRYLTIKNIQEEDESDYHC | GADHGSGSNFV |
| Vλ5-4 | QPVLTQSSSASASLGSSVKLTCT | LSSGHSS------YIIA | WHQQQPGKAPRYLMK | LEGSGSY-NKGS | GVPDRFSGSSSGADRYLTISNLQFEDEADYYC | ETWDSNT---- |
| Vλ5-6 | QLVLTQSPSASASLGASVKLTCT | LSSGHSS------YAIA | WHQQQPEKGPRYLMK | LNSDGSH-SKGD | GIPDRFSGSSSGAERYLTISSLQSEDEADYYC | QTWGTG----- |
| Human non-editor light chains | ||||||
| VκA2 | DIVMTQTPLSLSVTPGQPASISC | KSSQSLLHSD-GKTYLY | WYLQKPGQPPQLLIY | EVSNRFS----- | GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC | MQSIQLP---- |
| VκA17 | DVVMTQSPLSLPVTLGQPASISC | RSSQSLVYSD-GNTYLN | WFQQRPGQSPRRLIY | KVSNRDS----- | GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC | MQGTHWP---- |
| VκA19 | DIVMTQSPLSLPVTPGEPASISC | RSSQSLLHSN-GYNYLD | WYLQKPGQSPQLLIY | LGSNRAS----- | GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC | MQALQTP---- |
| VκA20 | DIQMTQSPSSLSASVGDRVTITC | RASQGISN------YLA | WYQQKPGKVPKLLIY | AASTLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDVATYYC | QKYNSAP---- |
| VκA23 | DIVMTQTPLSSPVTLGQPASISC | RSSQSLVHSD-GNTYLS | WLQQRPGQPPRLLIY | KISNRFS----- | GVPDRFSGSGAGTDFTLKISRVEAEDVGVYYC | MQATQFP---- |
| VκA26 | EIVLTQSPDFQSVTPKEKVTITC | RASQSIGSS------LH | WYQQKPDQSPKLLIK | YASQSFS----- | GVPSRFSGSGSGTDFTLTINSLEAEDAATYYC | HQSSSLP---- |
| VκA27 | EIVLTQSPGTLSLSPGERATLSC | RASQSVSSS-----YLA | WYQQKPGQAPRLLIY | GASSRAT----- | GIPDRFSGSGSGTDFTLTISRLEPEDFAVYYC | QQYGSSP---- |
| VκA30 | DIQMTQSPSSLSASVGDRVTITC | RASQGIRN------DLG | WYQQKPGKAPKRLIY | AASSLQS----- | GVPSRFSGSGSGTEFTLTISSLQPEDFATYYC | LQHNSYP---- |
| VκB3 | DIVMTQSPDSLAVSLGERATINC | KSSQSVLYSSNNKNYLA | WYQQKPGQPPKLLIY | WASTRES----- | GVPDRFSGSGSGTDFTLTISSLQAEDVAVYYC | QQYYSTP---- |
| VκL1 | DIQMTQSPSSLSASVGDRVTITC | RASQGISN------YLA | WFQQKPGKAPKSLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQYNSYP---- |
| VκL2 | EIVMTQSPATLSVSPGERATLSC | RASQSVSSN------LA | WYQQKPGQAPRLLIY | GASTRAT----- | GIPARFSGSGSGTEFTLTISSLQSEDFAVYYC | QQYNNWP---- |
| VκL5 | DIQMTQSPSSVSASVGDRVTITC | RASQGISS------WLA | WYQQKPGKAPKLLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQANSFP---- |
| VκL6 | EIVLTQSPATLSLSPGERATLSC | RASQSVSS------YLA | WYQQKPGQAPRLLIY | DASNRAT----- | GIPARFSGSGSGTDFTLTISSLEPEDFAVYYC | QQRSNWP---- |
| VκL8 | DIQLTQSPSFLSASVGDRVTITC | RASQGISS------YLA | WYQQKPGKAPKLLIY | AASTLQS----- | GVPSRFSGSGSGTEFTLTISSLQPEDFATYYC | QQLNSYP---- |
| VκL9 | AIRMTQSPSSFSASTGDRVTITC | RASQGISS------YLA | WYQQKPGKAPKLLIY | AASTLQS----- | GVPSRFSGSGSGTEFTLTISSLQPEDFATYYC | QQLNSYP---- |
| VκL12a | DIQMTQSPSTLSASVGDRVTITC | RASQSISS------WLA | WYQQKPGKAPKLLIY | KASSLES----- | GVPSRFSGSGSGTEFTLTISSLQPDDFATYYC | QQYNSYSP--- |
| VκL4/18a | AIQLTQSPSSLSASVGDRVTITC | RASQGISS------ALA | WYQQKPGKAPKLLIY | DASSLES----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQFNSYP---- |
| L23 | AIRMTQSPFSLSASVGDRVTITC | WASQGISS------YLA | WYQQKPAKAPKLFIY | YASSLQS----- | GVPSRFSGSGSGTDYTLTISSLQPEDFATYYC | QQYYSTP---- |
| L24 | VIWMTQSPSLLSASTGDRVTISC | RMSQGISS------YLA | WYQQKPGKAPELLIY | AASTLQS----- | GVPSRFSGSGSGTDFTLTISCLQSEDFATYYC | QQYYSFP---- |
| Name | FW1 | CDR1 | FW2 | CDR2 | FW3 | CDR3 |
| Mouse editor light chains | ||||||
| VκBt20 | STTVTQSPASLSMAIGEKVTIRC | ITSTDIDD------DMN | WYQQKPGEPPKLLIS | EGNTLRP----- | GVPSRFSSSGYGTDFVFTIENMLSEDVADYYCL | QSDNLP---- |
| VκBw20 | ETTVTQSPASLSVATGEKVTIRC | ITSTDIDD------DMN | WYQQKPGEPPKLLIS | EGNTLRP----- | GVPSRFSSSGYGTDFVFTIENTLSEDVADYYCL | QSDNMP---- |
| Vκ21-4 | DIVLTQSPASLAVSLGQRATISC | KASQS-VDYD-GDSYMN | WYQQKPGQPPKLLIY | AASNLES----- | GIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQ | QSNEDP---- |
| Vκ12-46 | DIQMTQSPASLSVSVGETVTITC | RASENIYS------NLA | WYQQKQGKSPQLLVY | AATNLAD----- | GVPSRFSGSGSGTQYSLKINSLQSEDFGSYYCQ | HFWGTP---- |
| VκGj38c | DIQMTQSPSSLSASLGGKVTITC | KASQDINK------YIA | WYQHKPGKGPRLLIH | YTSTLQP----- | GIPSRFSGSGSGRDYSFSISNLEPEDIATYYCL | QYDNLL---- |
| VλX | QLVLTQSS-SASFSLGASAKLTC | TLSSQHST-----YTIE | WYQQQPLKPPKYVME | LKKDGSH-STGD | GIPDRFSGSSSGADRYLSISNIQPEDEAIYIC | GVGDTIKEQFV |
| Human potential editor light chains | ||||||
| VκO8/O18 | DIQMTQSPSSLSASVGDRVTITC | QASQDISN------YLN | WYQQKPGKAPKLLIY | DASNLET----- | GVPSRFSGSGSGTDFTFTISSLQPEDIATYYC | QQYDNLP---- |
| VκL11 | AIQMTQSPSSLSASVGDRVTITC | RASQGIRN------DLG | WYQQKPGKAPKLLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | LQDYNYP---- |
| VκO2/O12 | DIQMTQSPSSLSASVGDRVTITC | RASQSISS------YLN | WYQQKPGKAPKLLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQSYSTP---- |
| Vλ5-1 | LPVLTQPPSASALLGASIKLTCT | LSSEHST------YTIE | WYQQRPGRSPQYIMK | VKSDGSH-SKGD | GIPDRFMGSSSGADRYLTFSNLQSDDEAEYHC | GESHTIDGQVG |
| Vλ5-2 | QPVLTQPPSASASLGASVTLTCT | LSSGYSN------YKVD | WYQQRPGKGPRFVMR | VGTGGIVGSKGD | GIPDRFSVLGSGLNRYLTIKNIQEEDESDYHC | GADHGSGSNFV |
| Vλ5-4 | QPVLTQSSSASASLGSSVKLTCT | LSSGHSS------YIIA | WHQQQPGKAPRYLMK | LEGSGSY-NKGS | GVPDRFSGSSSGADRYLTISNLQFEDEADYYC | ETWDSNT---- |
| Vλ5-6 | QLVLTQSPSASASLGASVKLTCT | LSSGHSS------YAIA | WHQQQPEKGPRYLMK | LNSDGSH-SKGD | GIPDRFSGSSSGAERYLTISSLQSEDEADYYC | QTWGTG----- |
| Human non-editor light chains | ||||||
| VκA2 | DIVMTQTPLSLSVTPGQPASISC | KSSQSLLHSD-GKTYLY | WYLQKPGQPPQLLIY | EVSNRFS----- | GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC | MQSIQLP---- |
| VκA17 | DVVMTQSPLSLPVTLGQPASISC | RSSQSLVYSD-GNTYLN | WFQQRPGQSPRRLIY | KVSNRDS----- | GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC | MQGTHWP---- |
| VκA19 | DIVMTQSPLSLPVTPGEPASISC | RSSQSLLHSN-GYNYLD | WYLQKPGQSPQLLIY | LGSNRAS----- | GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC | MQALQTP---- |
| VκA20 | DIQMTQSPSSLSASVGDRVTITC | RASQGISN------YLA | WYQQKPGKVPKLLIY | AASTLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDVATYYC | QKYNSAP---- |
| VκA23 | DIVMTQTPLSSPVTLGQPASISC | RSSQSLVHSD-GNTYLS | WLQQRPGQPPRLLIY | KISNRFS----- | GVPDRFSGSGAGTDFTLKISRVEAEDVGVYYC | MQATQFP---- |
| VκA26 | EIVLTQSPDFQSVTPKEKVTITC | RASQSIGSS------LH | WYQQKPDQSPKLLIK | YASQSFS----- | GVPSRFSGSGSGTDFTLTINSLEAEDAATYYC | HQSSSLP---- |
| VκA27 | EIVLTQSPGTLSLSPGERATLSC | RASQSVSSS-----YLA | WYQQKPGQAPRLLIY | GASSRAT----- | GIPDRFSGSGSGTDFTLTISRLEPEDFAVYYC | QQYGSSP---- |
| VκA30 | DIQMTQSPSSLSASVGDRVTITC | RASQGIRN------DLG | WYQQKPGKAPKRLIY | AASSLQS----- | GVPSRFSGSGSGTEFTLTISSLQPEDFATYYC | LQHNSYP---- |
| VκB3 | DIVMTQSPDSLAVSLGERATINC | KSSQSVLYSSNNKNYLA | WYQQKPGQPPKLLIY | WASTRES----- | GVPDRFSGSGSGTDFTLTISSLQAEDVAVYYC | QQYYSTP---- |
| VκL1 | DIQMTQSPSSLSASVGDRVTITC | RASQGISN------YLA | WFQQKPGKAPKSLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQYNSYP---- |
| VκL2 | EIVMTQSPATLSVSPGERATLSC | RASQSVSSN------LA | WYQQKPGQAPRLLIY | GASTRAT----- | GIPARFSGSGSGTEFTLTISSLQSEDFAVYYC | QQYNNWP---- |
| VκL5 | DIQMTQSPSSVSASVGDRVTITC | RASQGISS------WLA | WYQQKPGKAPKLLIY | AASSLQS----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQANSFP---- |
| VκL6 | EIVLTQSPATLSLSPGERATLSC | RASQSVSS------YLA | WYQQKPGQAPRLLIY | DASNRAT----- | GIPARFSGSGSGTDFTLTISSLEPEDFAVYYC | QQRSNWP---- |
| VκL8 | DIQLTQSPSFLSASVGDRVTITC | RASQGISS------YLA | WYQQKPGKAPKLLIY | AASTLQS----- | GVPSRFSGSGSGTEFTLTISSLQPEDFATYYC | QQLNSYP---- |
| VκL9 | AIRMTQSPSSFSASTGDRVTITC | RASQGISS------YLA | WYQQKPGKAPKLLIY | AASTLQS----- | GVPSRFSGSGSGTEFTLTISSLQPEDFATYYC | QQLNSYP---- |
| VκL12a | DIQMTQSPSTLSASVGDRVTITC | RASQSISS------WLA | WYQQKPGKAPKLLIY | KASSLES----- | GVPSRFSGSGSGTEFTLTISSLQPDDFATYYC | QQYNSYSP--- |
| VκL4/18a | AIQLTQSPSSLSASVGDRVTITC | RASQGISS------ALA | WYQQKPGKAPKLLIY | DASSLES----- | GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC | QQFNSYP---- |
| L23 | AIRMTQSPFSLSASVGDRVTITC | WASQGISS------YLA | WYQQKPAKAPKLFIY | YASSLQS----- | GVPSRFSGSGSGTDYTLTISSLQPEDFATYYC | QQYYSTP---- |
| L24 | VIWMTQSPSLLSASTGDRVTISC | RMSQGISS------YLA | WYQQKPGKAPELLIY | AASTLQS----- | GVPSRFSGSGSGTDFTLTISCLQSEDFATYYC | QQYYSFP---- |
Framework (FW) and CDR regions are identified according to Kabat definition, Asp residues (D) are underlined in CDR regions. Four Ds in CDRs are not underlined: (1) in Vk21-4 CDR1, (2) in VkA19 CDR1, (3) inVkL6 CDR2, and (4) in VkL4/18a CDR2. Not all human L chains listed in the table, but only those that were found in our survey.